Invention Application
US20160052854A1 METAL-CATALYZED COUPLING OF ARYL AND VINYL HALIDES WITH ALPHA, ALPHA-DIFLUOROCARBONYL COMPOUNDS
有权
与ALPHA，ALPHA-DIFLOCOBONYL化合物的芳基和乙烯基金属的金属催化偶联
- Patent Title: METAL-CATALYZED COUPLING OF ARYL AND VINYL HALIDES WITH ALPHA, ALPHA-DIFLUOROCARBONYL COMPOUNDS
- Patent Title (中): 与ALPHA，ALPHA-DIFLOCOBONYL化合物的芳基和乙烯基金属的金属催化偶联
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Application No.: US14782402Application Date: 2014-04-07
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Publication No.: US20160052854A1Publication Date: 2016-02-25
- Inventor: John F. HARTWIG , Shaozhong GE , Wojciech CHAKADAJ
- Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
- International Application: PCT/US14/33227 WO 20140407
- Main IPC: C07C45/68
- IPC: C07C45/68 ; C07F15/00 ; C07C319/20 ; C07C67/343 ; C07C201/12 ; C07D317/54 ; C07F7/08 ; C07D213/50 ; C07D215/14 ; C07D217/18 ; C07C221/00 ; C07C67/297 ; C07D317/26 ; C07C269/06 ; C07C45/00 ; C07C17/361 ; C07C67/42 ; C07C41/18 ; C07D317/16 ; C07D215/12 ; C07D295/104 ; C07D333/24 ; C07D213/56 ; C07C231/12 ; C07C323/22 ; C07C69/76 ; C07C205/45 ; C07C225/22 ; C07C69/612 ; B01J31/24 ; C07B39/00
Abstract:
The coupling of aryl, heteroaryl, and vinyl halides with α,α-difluoroketones or silyl ethers or siylenol ethers of α,α-difluoroketones and α,α-difluoroamides and esters are described. Further derivatization of the coupling products (such as ketone cleavage and Baeyer-Villiger oxidation) is also described.
Public/Granted literature
- US09598340B2 Metal-catalyzed coupling of aryl and vinyl halides with alpha, alpha-difluorocarbonyl compounds Public/Granted day:2017-03-21
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