Invention Application
- Patent Title: POLYPEPTIDES WITH PERMEASE ACTIVITY
- Patent Title (中): 具有过氧化物酶活性的多糖
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Application No.: US14895742Application Date: 2014-06-04
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Publication No.: US20160122400A1Publication Date: 2016-05-05
- Inventor: Paul KLAASSEN , Paulus Petrus DE WAAL , Rene Marcel DE JONG , Arnold Jacob Mattieu DRIESSEN , Jeroen Gerben NIJLAND , Hyun Yong SHIN
- Applicant: DSM IP ASSETS B.V.
- Priority: EP13170644.2 20130605; EP13170646.7 20130605; EP13170648.3 20130605; EP13197988.2 20131218; EP14160772.1 20140319; EP14164270.2 20140410
- International Application: PCT/EP2014/061632 WO 20140604
- Main IPC: C07K14/395
- IPC: C07K14/395 ; C12P19/02
Abstract:
The invention relates to a polypeptide having one or more substitution at a position corresponding to position 339 or 376 of SEQ ID NO: 59, wherein the polypeptide is a member of the Major Facilitator Superfamily (MFS). In an embodiment, the substitution is at position corresponding to 376 and wherein the amino acid at that position is replaced by an amino acid that has a van der Waals volume of 80 to 138 Å3 and a side chain hydrophobicity of 10 to 100 ΔtR.
Public/Granted literature
- US10000537B2 Polypeptides with permease activity Public/Granted day:2018-06-19
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