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    LIPOLYTIC ENZYME VARIANTS
    1.
    发明申请
    LIPOLYTIC ENZYME VARIANTS 有权

    公开(公告)号：US20210087542A1

    公开(公告)日：2021-03-25

    申请号：US17109759

    申请日：2020-12-02

    Applicant: DSM IP ASSETS B.V.

    Inventor： Rene Marcel DE JONG ,  Chantal CHRISTIS ,  Neil CARR

    IPC: C12N9/20 ,  A21D8/04

    Abstract: The present disclosure describes a variant polypeptide having lipolytic activity, wherein the variant has an amino acid sequence which, when aligned with the amino acid sequence as set out in SEQ ID NO: 2, comprises at least one substitution of an amino acid residue at a position corresponding to any of the positions 113, 122, 138, 141, 179, 282, 284, 286, 295, said positions being defined with reference to SEQ ID NO: 2, and wherein said variant has at least 70% identity with the mature polypeptide having lipolytic activity as set out in SEQ ID NO: 2. Such a variant polypeptide may be used in the preparation of a baked product.

    POLYPEPTIDES WITH PERMEASE ACTIVITY
    2.
    发明申请
    POLYPEPTIDES WITH PERMEASE ACTIVITY 有权
    具有过氧化物酶活性的多糖

    公开(公告)号：US20160122400A1

    公开(公告)日：2016-05-05

    申请号：US14895742

    申请日：2014-06-04

    Applicant: DSM IP ASSETS B.V.

    Inventor： Paul KLAASSEN ,  Paulus Petrus DE WAAL ,  Rene Marcel DE JONG ,  Arnold Jacob Mattieu DRIESSEN ,  Jeroen Gerben NIJLAND ,  Hyun Yong SHIN

    IPC: C07K14/395 ,  C12P19/02

    CPC classification number: C07K14/395 ,  C12P19/02

    Abstract: The invention relates to a polypeptide having one or more substitution at a position corresponding to position 339 or 376 of SEQ ID NO: 59, wherein the polypeptide is a member of the Major Facilitator Superfamily (MFS). In an embodiment, the substitution is at position corresponding to 376 and wherein the amino acid at that position is replaced by an amino acid that has a van der Waals volume of 80 to 138 Å3 and a side chain hydrophobicity of 10 to 100 ΔtR.

    Abstract translation: 本发明涉及在对应于SEQ ID NO：59的位置339或376的位置具有一个或多个取代的多肽，其中多肽是主要促进剂超家族（MFS）的成员。 在一个实施方案中，取代位于对应于376的位置，并且其中该位置处的氨基酸被具有范德华体积为80至138埃的氨基酸和10至100重量％的侧链疏水性 。

    LIPOLYTIC ENZYME VARIANTS
    3.
    发明申请
    LIPOLYTIC ENZYME VARIANTS 审中-公开

    公开(公告)号：US20190338261A1

    公开(公告)日：2019-11-07

    申请号：US16471121

    申请日：2017-12-19

    Applicant: DSM IP Assets B.V.

    Inventor： Rene Marcel DE JONG ,  Chantal CHRISTIS ,  Neil CARR

    IPC: C12N9/20 ,  A21D8/04

    Abstract: The present disclosure describes a variant polypeptide having lipolytic activity, wherein the variant has an amino acid sequence which, when aligned with the amino acid sequence as set out in SEQ ID NO: 2, comprises at least one substitution of an amino acid residue at a position corresponding to any of the positions 113, 122, 138, 141, 179, 282, 284, 286, 295, said positions being defined with reference to SEQ ID NO: 2, and wherein said variant has at least 70% identity with the mature polypeptide having lipolytic activity as set out in SEQ ID NO: 2.Such a variant polypeptide may be used in the preparation of a baked product.

    MALATE DEHYROGENASES
    4.
    发明申请
    MALATE DEHYROGENASES 审中-公开

    公开(公告)号：US20190225947A1

    公开(公告)日：2019-07-25

    申请号：US16316988

    申请日：2017-07-11

    Applicant: DSM IP ASSETS B.V.

    Inventor： Alrik Pieter LOS ,  Rene Marcel DE JONG ,  Remko Tsjibbe WINTER ,  Ben DEN DULK

    IPC: C12N9/04 ,  C12P7/46 ,  C12R1/865

    Abstract: The present invention relates to a recombinant host cell which is capable of producing a dicarboxylic acid and which comprises a mutant malate dehydrogenase resulting in an increased production of the dicarboxylic acid. The invention also relates to a process for producing a dicarboxylic acid, which method comprises fermenting said recombinant host cell in a suitable fermentation medium and producing the dicarboxylic acid.

    LIPOLYTIC ENZYME VARIANTS
    5.
    发明申请
    LIPOLYTIC ENZYME VARIANTS 审中-公开

    公开(公告)号：US20190335764A1

    公开(公告)日：2019-11-07

    申请号：US16471159

    申请日：2017-12-19

    Applicant: DSM IP Assets B.V.

    Inventor： Rene Marcel DE JONG ,  Chantal CHRISTIS ,  Neil CARR

    IPC: A21D8/04 ,  C12N9/20 ,  C12N15/52

    Abstract: The present disclosure describes a variant polypeptide having lipolytic activity, wherein the variant has an amino acid sequence which, when aligned with the amino acid sequence as set out in SEQ ID NO: 2, comprises at least one substitution of an amino acid residue at a position corresponding to any of the positions 53, 112, 141, 178, 179, 182, 202, 203, 235, 282, 284,said positions being defined with reference to SEQ ID NO: 2, and wherein said variant has at least 70% identity with the mature polypeptide having lipolytic activity as set out in SEQ ID NO: 2.Such a variant polypeptide may be used in the preparation of a baked product.

    ALPHA-AMYLASE VARIANTS
    9.
    发明申请
    ALPHA-AMYLASE VARIANTS 有权

    公开(公告)号：US20140248397A1

    公开(公告)日：2014-09-04

    申请号：US13842344

    申请日：2013-03-15

    Applicant: DSM IP ASSETS B.V.

    Inventor： Rene Marcel DE JONG ,  Hanna Elisabet ABBAS

    IPC: A21D8/04 ,  C12N9/28

    CPC classification number: A21D8/042 ,  C12N9/2417 ,  C12Y302/01001

    Abstract: A variant polypeptide having alpha-amylase activity, wherein the variant has an amino acid sequence which, when aligned with the alpha-amylase comprising the sequence set out in SEQ ID NO: 2, comprises at least one substitution of an amino acid residue corresponding to any of amino acids 4, 6, 13, 14, 15, 16, 20, 45, 47, 51, 54, 61, 68, 69, 70, 71, 72, 73, 74, 75, 77, 78, 80, 82, 87, 88, 94, 95, 100, 103, 104, 117, 124, 125, 126, 128, 130, 133, 134, 136, 143, 144, 146, 168, 174, 177, 178, 183, 186, 188, 189, 190, 194, 195, 199, 200, 201, 204, 207, 210, 214, 217, 219, 222, 225, 227, 233, 234, 235, 236, 240, 251, 252, 254, 258, 259, 260, 261, 262, 263, 264, 266, 267, 269, 271, 273, 281, 282, 283, 284, 286, 288, 299, 322, 323, 325, 327, 328, 331, 334, 350, 356, 358, 367, 370, 371, 374, 377, 378, 388, 391, 414, 421, 422, 445, 450, 467, 488, 505, 536, 548, 583, 588, 603, 637, 648, 651, 652, 660, 676, 677,said positions being defined with reference to SEQ ID NO: 2 and wherein the variant has one or more altered properties as compared with a reference polypeptide having alpha-amylase activity. Such a variant polypeptide may be used in the preparation of a baked product.

    Abstract translation: 具有α-淀粉酶活性的变体多肽，其中所述变体具有当与包含SEQ ID NO：2所示的序列的α-淀粉酶比对时的氨基酸序列包含至少一个对应于 任何氨基酸4,6,13,14,15,16,20,45,47,51,54,61,68,69,70,71,72,73,74,75,77,78,80， 82,87,88,94,95,100,103,104,117,124,125,126,128,130,133,134,136,143,144,146,168,174,177,178,183， 186,188,189,190,194,195,199,200,2201,204,207,210,214,217,219,222,225,227,233,234,235,236,240,251,252,252,218,218,218,218,29,29,29,29,29,29,29,29,29,29,29,29,29,29,29,29,29,29,29,29,29,29,29,29,29,29,29,29,29,29,29,29,29,2 254,258,258,260,261,262,263,264,266,262,263,264,266,276,263,264,266,276,263,267,271,273,281,282,283,284,286,288,29,322,236,265,276,262,263,264,266,262,263,264,266,266,263,264,266,266,263,264,266,266,263,264,266,266,263,264,266,266,263,264,266,266,263 331,334,350,356,358,367,370,371,374,377,378,388,391,414,421,422,445,450,467,488,505,536,548,583,558,538,348,336,350,356,358,367,350,356,358,367,370,356,358,367,370,356,358,367,375,356,358,367,370,356,358,367,370,356,358,367,375,356,358,367,375,356,358 603,637,648,651,652,660,676,677，所述位置参考SEQ ID NO：2定义，其中变体ha 与具有α-淀粉酶活性的参考多肽相比，具有一个或多个改变的特性。 这样的变体多肽可用于制备焙烤产品。

    PHOSPHOLIPASE C
    10.
    发明申请
    PHOSPHOLIPASE C 审中-公开

    公开(公告)号：US20180134986A1

    公开(公告)日：2018-05-17

    申请号：US15564275

    申请日：2016-04-08

    Applicant: DSM IP ASSETS B.V.

    Inventor： Arjen SEIN ,  Rene Marcel DE JONG ,  Evert Tjeerd VAN RIJ ,  Willem BIJLEVELD ,  Maarten Hotse WILBRINK

    IPC: C11B3/00 ,  C12N9/16 ,  C12P7/64

    CPC classification number: C11B3/003 ,  C12N9/16 ,  C12P7/20 ,  C12P7/64 ,  C12P7/6445 ,  C12Y301/04003

    Abstract: The present invention relates to a polypeptide having phospholipase C activity, selected from the group consisting of i. a polypeptide comprising a mature polypeptide sequence of SEQ ID NO: 2; ii. a polypeptide that has least 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98% or 99% identity to the mature polypeptide sequence of SEQ ID NO: 2; iii. a polypeptide encoded by a nucleic acid that hybridizes under medium stringency, preferably under high stringency conditions to the complementary strand of the mature polypeptide coding sequence of SEQ ID NO:1; iv. a polypeptide encoded by a nucleic acid that has at least 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or 100% identity to the mature polypeptide coding sequence of SEQ ID NO: 1. A process for degumming a vegetable oil comprising contacting a vegetable oil comprising phospholipids with a polypeptide having phospholipase C activity of the invention or a composition of the invention, wherein phospholipids are hydrolysed into diacylglycerol and phosphate ester and/or phosphate, separating the phosphate ester and/or phosphate from the vegetable oil wherein a degummed vegetable oil is obtained.

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