According to one embodiment, a processor includes an instruction decoder to receive an instruction to process a multiply-accumulate operation, the instruction having a first operand, a second operand, a third operand, and a fourth operand. The first operand is to specify a first storage location to store an accumulated value; the second operand is to specify a second storage location to store a first value and a second value; and the third operand is to specify a third storage location to store a third value. The processor further includes an execution unit coupled to the instruction decoder to perform the multiply-accumulate operation to multiply the first value with the second value to generate a multiply result and to accumulate the multiply result and at least a portion of a third value to an accumulated value based on the fourth operand.