Invention Application
- Patent Title: METHOD OF CUTTING OUT RNA OLIGONUCLEOTIDE
- Patent Title (中): 切出RNA寡核苷酸的方法
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Application No.: US15185875Application Date: 2016-06-17
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Publication No.: US20170002038A1Publication Date: 2017-01-05
- Inventor: Shohei HORIE , Tatsuya KONISHI , Kenjiro MORI , Eri MAETA , Tsuyoshi MUKOBATA , Masafumi IWAMOTO
- Applicant: Nitto Denko Corporation
- Applicant Address: JP Osaka
- Assignee: Nitto Denko Corporation
- Current Assignee: Nitto Denko Corporation
- Current Assignee Address: JP Osaka
- Priority: JP2015-123222 20150618
- Main IPC: C07H21/02
- IPC: C07H21/02 ; C07H1/06

Abstract:
The invention provides a cut-out method capable of suppressing production of a byproduct, wherein the object RNA oligonucleotide is not cleaved from a universal linker, which is produced in cutting out the object RNA oligonucleotide from the universal support, and capable of increasing the yield of the object RNA oligonucleotide. The RNA oligonucleotide cut-out method includes a step of bringing a universal support supporting an RNA oligonucleotide in contact with an aqueous solution containing alkylamine and a monovalent inorganic salt.
Public/Granted literature
- US10138266B2 Method of cutting out RNA oligonucleotide Public/Granted day:2018-11-27
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