Systems, apparatuses, and methods for utilizing a programmable memory command sequencer to generate multiple commands from a single memory request. A sequencer receives requests from a host processor and utilizes any of a plurality of programmable routines in response to determining that a given request meets specific criteria. A given programmable routine generates a plurality of memory commands which are then conveyed to a local memory controller and/or one or more remote memory controllers. The host processor programs the sequencer at boot time and updates the sequencer at runtime in response to changing application behavior. In various embodiments, the sequencer generates a variety of error correction routines in response to different requests received from the host processor.