Invention Application
US20170067096A1 Nanoscale Imaging of Proteins and Nucleic Acids via Expansion Microscopy
审中-公开
蛋白质和核酸通过扩张显微镜的纳米成像
- Patent Title: Nanoscale Imaging of Proteins and Nucleic Acids via Expansion Microscopy
- Patent Title (中): 蛋白质和核酸通过扩张显微镜的纳米成像
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Application No.: US15229539Application Date: 2016-08-05
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Publication No.: US20170067096A1Publication Date: 2017-03-09
- Inventor: Asmamaw Wassie , Fei Chen , Edward Stuart Boyden , Shahar Alon
- Applicant: Massachusetts Institute of Technology
- Main IPC: C12Q1/68
- IPC: C12Q1/68
Abstract:
The invention enables in situ genomic and transcriptomic assessment of nucleic acids to be conducted in biological specimens that have been physically expanded. The invention leverages the techniques for expansion microscopy (ExM) to provide new methods for in situ genomic and transcriptomic assessment of nucleic in a new process referred to herein as “expansion fluorescent in situ hybridization” (ExFISH).
Public/Granted literature
- US10364457B2 Nanoscale imaging of proteins and nucleic acids via expansion microscopy Public/Granted day:2019-07-30
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