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    Intravascular Device
    5.
    发明申请
    Intravascular Device 审中-公开

    公开(公告)号：US20190175372A1

    公开(公告)日：2019-06-13

    申请号：US16043122

    申请日：2018-07-23

    Applicant: Massachusetts Institute of Technology ,  Washington University

    Inventor： Edward Stuart Boyden ,  Giovanni Talei Franzesi ,  Christian Wentz ,  Nir Grossman ,  Elazer R. Edelman ,  Colin Derdeyn ,  Eric Leuthardt

    IPC: A61F2/90 ,  A61B5/00 ,  A61N2/02 ,  A61B5/04 ,  A61B5/07 ,  A61N1/36 ,  A61B5/026

    Abstract: An electronic intravascular device is placed in tight contact with vessel walls and is used for electrical stimulation and/or electrical recording of the vessel wall and surrounding target tissue. The electrodes may operate via connectors interfacing them to external hardware or may incorporate electronics to allow wireless power, information transfer, and control. The device includes an internal skeleton, a flexible substrate attached to the exterior of the skeleton, at least one pair of electrodes located on the substrate, and power and control circuitry connected to the electrodes. The power and control circuitry may include connectors for direct powering of the electrodes or circuit elements for wireless powering of the device by RF-based, optical-based, ultrasound-based, piezoelectric, or vibrational energy harvesting methods. The power and control circuitry may include circuit elements for wireless communication, including between the device and the external environment, and may include on-board processing for control of the electrodes.

    Nanoscale Imaging of Proteins and Nucleic Acids via Expansion Microscopy
    6.
    发明申请
    Nanoscale Imaging of Proteins and Nucleic Acids via Expansion Microscopy 审中-公开
    蛋白质和核酸通过扩张显微镜的纳米成像

    公开(公告)号：US20170067096A1

    公开(公告)日：2017-03-09

    申请号：US15229539

    申请日：2016-08-05

    Applicant: Massachusetts Institute of Technology

    Inventor： Asmamaw Wassie ,  Fei Chen ,  Edward Stuart Boyden ,  Shahar Alon

    IPC: C12Q1/68

    CPC classification number: C12Q1/6841 ,  C12Q1/6806 ,  G01N1/36 ,  G01N2001/364

    Abstract: The invention enables in situ genomic and transcriptomic assessment of nucleic acids to be conducted in biological specimens that have been physically expanded. The invention leverages the techniques for expansion microscopy (ExM) to provide new methods for in situ genomic and transcriptomic assessment of nucleic in a new process referred to herein as “expansion fluorescent in situ hybridization” (ExFISH).

    Abstract translation: 本发明使得能够在物理扩展的生物标本中进行核酸的原位基因组和转录组学评估。 本发明利用扩展显微镜技术（ExM）提供了在本文称为“扩增荧光原位杂交”（ExFISH）的新方法中对核酸进行原位基因组和转录组学评估的新方法。

    ITERATIVE EXPANSION MICROSCOPY
    7.
    发明申请
    ITERATIVE EXPANSION MICROSCOPY 审中-公开
    迭代扩展显微镜

    公开(公告)号：US20160305856A1

    公开(公告)日：2016-10-20

    申请号：US15098799

    申请日：2016-04-14

    Applicant: Massachusetts Institute of Technology

    Inventor： Edward Stuart Boyden ,  Jae-Byum Chang ,  Fei Chen ,  Paul Warren Tillberg

    IPC: G01N1/30 ,  G01N33/58

    CPC classification number: G01N33/582 ,  G01N1/36 ,  G01N1/4044 ,  G01N2001/302 ,  G01N2001/307

    Abstract: The present invention leverages the techniques for expansion microscopy (ExM) to provide improved high-throughput super-resolution whole-organ imaging methodology to image protein architectures over whole organs with nanoscale resolution by using high-throughput microscopes in combination with samples that have been iteratively expanded more than once, in a method referred to herein as “iterative expansion microscopy” (iExM). In the ExM method, biological samples of interest are permeated with a swellable material that results in the sample becoming embedded in the swellable material, and then the sample can be expanded isotropically in three dimensions The process of iteratively expanding the samples can be applied to samples that have been already expanded using ExM techniques one or more additional times to iteratively expand them such that, for example, a 5-fold expanded specimen can be expanded again 3- to 4-fold, resulting in as much as a 17- to 19-fold or more linear expansion.

    Abstract translation: 本发明利用扩展显微镜技术（ExM）来提供改进的高通量超分辨率全器官成像方法，以通过使用高通量显微镜与已经迭代的样品组合来对纳米尺度分辨率的整个器官进行成像蛋白质结构 在这里称为“迭代显微镜”（iExM）的方法中多次扩展。 在ExM方法中，感兴趣的生物样品渗透出可膨胀的材料，导致样品变得嵌入可溶胀材料中，然后样品可以在三维方向上各向同性地膨胀。迭代扩展样品的过程可以应用于样品 已经使用ExM技术已经扩展了一个或多个时间来迭代地扩展它们，使得例如5倍扩展的样本可以再次扩展3到4倍，导致17到19 倍或更多的线性膨胀。

    Membrane probes for expansion microscopy
    8.
    发明授权
    Membrane probes for expansion microscopy 有权

    公开(公告)号：US12265004B2

    公开(公告)日：2025-04-01

    申请号：US17089003

    申请日：2020-11-04

    Applicant: Massachusetts Institute of Technology

    Inventor： Edward Stuart Boyden ,  Jeong Seuk Kang ,  Emmanouil D. Karagiannis

    IPC: G01N1/36 ,  C07K7/06 ,  G01N1/30 ,  G02B21/36

    Abstract: The present invention provides compositions and methods that allow lipid membranes to be imaged optically at nanoscale resolution via a lipid-optimized form of expansion microscopy, also referred to as membrane expansion microscopy (mExM). mExM, via a post-expansion antibody labeling protocol, enables protein-lipid relationships to be imaged in organelles such as mitochondria, the endoplasmic reticulum, the nuclear membrane, and the Golgi apparatus. mExM may be of use in a variety of biological contexts, including the study of cell-cell interactions, intracellular transport, and neural connectomics.

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