发明申请
- 专利标题: TRANSMUCOSAL DELIVERY OF LAQUINIMOD BY ORAL PATCHES
- 专利标题(中): 通过口头贴子传递LAQUINIMOD
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申请号: US15123208申请日: 2015-03-13
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公开(公告)号: US20170071869A1公开(公告)日: 2017-03-16
- 发明人: Ralph Stefan , Hans Juergen Mika , Claudia Lauer , Dirk Schenk , Sabine Prohl
- 申请人: Ralph Stefan , Hans Juergen Mika , Claudia Lauer , Dirk Schenk , Sabine Prohl
- 申请人地址: IL Petach Tikva
- 专利权人: Teva Pharmaceutical Industries Ltd.
- 当前专利权人: Teva Pharmaceutical Industries Ltd.
- 当前专利权人地址: IL Petach Tikva
- 国际申请: PCT/US2015/020432 WO 20150313
- 主分类号: A61K9/70
- IPC分类号: A61K9/70 ; A61K31/4704 ; A61K9/00
摘要:
The subject invention provides an oral patch comprising: a) a liner; and b) a film composition thereon, the film composition comprising (i) laquinimod in an amount of about 0.1%-20% by weight of the film composition, and (ii) one or more film forming agents in a total amount of about 40%-90% by weight of the film composition. The subject invention also provides a method for delivering laquinimod across the oral mucosa of a subject, or for treating a human subject afflicted with a form of multiple sclerosis, comprising periodically administering to the human subject an oral patch as described herein. The subject invention also provides an oral patch as described herein for use in treating a human subject afflicted with a form of multiple sclerosis.