公开(公告)号：US20170071869A1

公开(公告)日：2017-03-16

申请号：US15123208

申请日：2015-03-13

申请人： Ralph Stefan ,  Hans Juergen Mika ,  Claudia Lauer ,  Dirk Schenk ,  Sabine Prohl

发明人： Ralph Stefan ,  Hans Juergen Mika ,  Claudia Lauer ,  Dirk Schenk ,  Sabine Prohl

IPC分类号： A61K9/70 ,  A61K31/4704 ,  A61K9/00

CPC分类号： A61K9/70 ,  A61K9/006 ,  A61K31/4704

摘要： The subject invention provides an oral patch comprising: a) a liner; and b) a film composition thereon, the film composition comprising (i) laquinimod in an amount of about 0.1%-20% by weight of the film composition, and (ii) one or more film forming agents in a total amount of about 40%-90% by weight of the film composition. The subject invention also provides a method for delivering laquinimod across the oral mucosa of a subject, or for treating a human subject afflicted with a form of multiple sclerosis, comprising periodically administering to the human subject an oral patch as described herein. The subject invention also provides an oral patch as described herein for use in treating a human subject afflicted with a form of multiple sclerosis.

摘要翻译： 本发明提供口腔贴剂，其包含：a）衬垫; 和b）其上的薄膜组合物，所述薄膜组合物包含（i）按所述薄膜组合物重量计约0.1％-20％重量的拉喹莫德，和（ii）一种或多种总成型量的成膜剂 ％-90重量％的膜组合物。 本发明还提供了一种用于递送穿过受试者的口腔粘膜的laquinimod或用于治疗患有多发性硬化症形式的人类受试者的方法，其包括向所述人类受试者施用本文所述的口腔贴剂。 本发明还提供如本文所述的用于治疗患有多发性硬化症形式的人类受试者的口腔贴剂。