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    TRANSMUCOSAL DELIVERY OF LAQUINIMOD BY ORAL PATCHES
    2.
    发明申请
    TRANSMUCOSAL DELIVERY OF LAQUINIMOD BY ORAL PATCHES 审中-公开
    通过口头贴子传递LAQUINIMOD

    公开(公告)号：US20170071869A1

    公开(公告)日：2017-03-16

    申请号：US15123208

    申请日：2015-03-13

    申请人： Ralph Stefan ,  Hans Juergen Mika ,  Claudia Lauer ,  Dirk Schenk ,  Sabine Prohl

    发明人： Ralph Stefan ,  Hans Juergen Mika ,  Claudia Lauer ,  Dirk Schenk ,  Sabine Prohl

    IPC分类号： A61K9/70 ,  A61K31/4704 ,  A61K9/00

    CPC分类号： A61K9/70 ,  A61K9/006 ,  A61K31/4704

    摘要： The subject invention provides an oral patch comprising: a) a liner; and b) a film composition thereon, the film composition comprising (i) laquinimod in an amount of about 0.1%-20% by weight of the film composition, and (ii) one or more film forming agents in a total amount of about 40%-90% by weight of the film composition. The subject invention also provides a method for delivering laquinimod across the oral mucosa of a subject, or for treating a human subject afflicted with a form of multiple sclerosis, comprising periodically administering to the human subject an oral patch as described herein. The subject invention also provides an oral patch as described herein for use in treating a human subject afflicted with a form of multiple sclerosis.

    摘要翻译： 本发明提供口腔贴剂，其包含：a）衬垫; 和b）其上的薄膜组合物，所述薄膜组合物包含（i）按所述薄膜组合物重量计约0.1％-20％重量的拉喹莫德，和（ii）一种或多种总成型量的成膜剂 ％-90重量％的膜组合物。 本发明还提供了一种用于递送穿过受试者的口腔粘膜的laquinimod或用于治疗患有多发性硬化症形式的人类受试者的方法，其包括向所述人类受试者施用本文所述的口腔贴剂。 本发明还提供如本文所述的用于治疗患有多发性硬化症形式的人类受试者的口腔贴剂。

    TRANSDERMAL FORMULATIONS OF LAQUINIMOD
    7.
    发明申请
    TRANSDERMAL FORMULATIONS OF LAQUINIMOD 审中-公开
    LAQUINIMOD的透皮配方

    公开(公告)号：US20160038435A1

    公开(公告)日：2016-02-11

    申请号：US14773658

    申请日：2014-03-13

    申请人： Ralph STEFAN ,  Hans-Juergen MIKA ,  Tanja PRIES ,  Dirk SCHENK ,  Sabine PROHL

    发明人： Ralph STEFAN ,  Hans-Juergen MIKA ,  Tanja PRIES ,  Dirk SCHENK ,  Sabine PROHL

    IPC分类号： A61K9/70 ,  A61K47/14 ,  A61K47/12 ,  A61K31/4704 ,  A61K47/10

    CPC分类号： A61K9/7061 ,  A61K9/7084 ,  A61K31/4704 ,  A61K47/10 ,  A61K47/12 ,  A61K47/14

    摘要： This invention provides a transdermal patch comprising a) a backing layer; b) a liner; c) optionally, a highly porous membrane; and d) a pharmaceutical composition comprising: (i) optionally, a pressure sensitive adhesive in an amount of up to about 95 wt % of the pharmaceutical composition, (ii) laquinimod in an amount of about 0.1-20 wt % of the pharmaceutical composition, and (iii) optionally, one or more permeation enhancers in a total amount of up to about 70 wt % of the pharmaceutical composition. This invention also provides a method for delivering laquinimod across the skin of the subject and for treating a human subject afflicted with a form of multiple sclerosis comprising administering to the skin of the subject a transdermal patch as described herein. This invention further provides a transdermal patch as described herein for use in treating a human subject afflicted with a form of multiple sclerosis.

    摘要翻译： 本发明提供一种透皮贴剂，其包含：a）背衬层; b）衬垫; c）任选地，高度多孔的膜; 和d）药物组合物，其包含：（i）任选地，所述药物组合物的至多约95重量％的量的压敏粘合剂，（ii）所述药物组合物的约0.1-20重量％的拉喹莫德 ，和（iii）任选的一种或多种渗透促进剂，其总量高达药物组合物的约70重量％。 本发明还提供了一种递送角质层跨越受试者皮肤并用于治疗患有多发性硬化症形式的人类受试者的方法，包括向受试者的皮肤施用如本文所述的透皮贴片。 本发明还提供了本文所述的用于治疗患有多发性硬化症形式的人类受试者的透皮贴剂。

    Non-contact sensing system having MEMS-based light source
    8.
    发明授权
    Non-contact sensing system having MEMS-based light source 有权
    具有基于MEMS的光源的非接触式感测系统

    公开(公告)号：US09204129B2

    公开(公告)日：2015-12-01

    申请号：US12943344

    申请日：2010-11-10

    申请人： Shyam P. Keshavmurthy ,  David Crowther ,  George C. Lin ,  Craig Manning ,  Martin P. Koskella ,  Brett Hibbard ,  Ralph Stefan ,  Jason Wilson ,  Richard Krakowski

    发明人： Shyam P. Keshavmurthy ,  David Crowther ,  George C. Lin ,  Craig Manning ,  Martin P. Koskella ,  Brett Hibbard ,  Ralph Stefan ,  Jason Wilson ,  Richard Krakowski

    IPC分类号： H04N13/02 ,  G01B11/245 ,  G01B11/25 ,  G01S17/48 ,  G01S17/87 ,  G01S17/89

    CPC分类号： H04N13/254 ,  G01B11/245 ,  G01B11/2518 ,  G01S17/48 ,  G01S17/87 ,  G01S17/89 ,  H04N13/239

    摘要： A non-contact sensing system is provided for acquiring three-dimensional contour information of an object. The system is comprised of: a light source subsystem operable to scan a point of light in an area of illumination; a first imaging device having a field of view arranged to intersect with the illumination area and operable to capture image data; and a second imaging device having a field of view arranged to intersect with the illumination area and operable to capture image data. A first control module is in data communication with the first imaging device to determine contour information for an object in the field of view of the first imaging device and report the contour information for the object in a common coordinate system. A second control module is in data communication with the second imaging device to determine contour information for the object in the field of view of the second imaging device and report the contour information for the object in the common coordinate system. Moreover, the light source subsystem is calibrated to report position of the point of light in the common coordinate system.

    摘要翻译： 提供了用于获取物体的三维轮廓信息的非接触感测系统。 该系统包括：可操作以扫描照明区域中的光点的光源子系统; 具有被布置成与照明区域相交并且可操作以捕获图像数据的视场的第一成像装置; 以及具有被布置成与照明区域相交并且可操作以捕获图像数据的视场的第二成像装置。 第一控制模块与第一成像设备进行数据通信，以确定第一成像设备的视野中的对象的轮廓信息，并且在公共坐标系中报告该对象的轮廓信息。 第二控制模块与第二成像装置进行数据通信，以确定第二成像装置的视野中的对象的轮廓信息，并且在公共坐标系中报告对象的轮廓信息。 此外，光源子系统被校准以报告在同一坐标系中的光点的位置。

    NON-CONTACT SENSING SYSTEM HAVING MEMS-BASED LIGHT SOURCE
    10.
    发明申请
    NON-CONTACT SENSING SYSTEM HAVING MEMS-BASED LIGHT SOURCE 有权
    具有基于MEMS的光源的非接触式感应系统

    公开(公告)号：US20120062706A1

    公开(公告)日：2012-03-15

    申请号：US12943344

    申请日：2010-11-10

    申请人： Shyam P. Keshavmurthy ,  David Crowther ,  George C. Lin ,  Craig Manning ,  Martin P. Koskella ,  Brett Hibbard ,  Ralph Stefan ,  Jason Wilson ,  Richard Krakowski

    发明人： Shyam P. Keshavmurthy ,  David Crowther ,  George C. Lin ,  Craig Manning ,  Martin P. Koskella ,  Brett Hibbard ,  Ralph Stefan ,  Jason Wilson ,  Richard Krakowski

    IPC分类号： H04N13/02

    CPC分类号： H04N13/254 ,  G01B11/245 ,  G01B11/2518 ,  G01S17/48 ,  G01S17/87 ,  G01S17/89 ,  H04N13/239

    摘要： A non-contact sensing system is provided for acquiring three-dimensional contour information of an object. The system is comprised of: a light source subsystem operable to scan a point of light in an area of illumination; a first imaging device having a field of view arranged to intersect with the illumination area and operable to capture image data; and a second imaging device having a field of view arranged to intersect with the illumination area and operable to capture image data. A first control module is in data communication with the first imaging device to determine contour information for an object in the field of view of the first imaging device and report the contour information for the object in a common coordinate system. A second control module is in data communication with the second imaging device to determine contour information for the object in the field of view of the second imaging device and report the contour information for the object in the common coordinate system. Moreover, the light source subsystem is calibrated to report position of the point of light in the common coordinate system.

    摘要翻译： 提供了用于获取物体的三维轮廓信息的非接触感测系统。 该系统包括：可操作以扫描照明区域中的光点的光源子系统; 具有被布置成与照明区域相交并且可操作以捕获图像数据的视场的第一成像装置; 以及具有被布置成与照明区域相交并且可操作以捕获图像数据的视场的第二成像装置。 第一控制模块与第一成像设备进行数据通信，以确定第一成像设备的视野中的对象的轮廓信息，并且在公共坐标系中报告该对象的轮廓信息。 第二控制模块与第二成像装置进行数据通信，以确定第二成像装置的视野中的对象的轮廓信息，并且在公共坐标系中报告对象的轮廓信息。 此外，光源子系统被校准以报告在同一坐标系中的光点的位置。