Invention Application
- Patent Title: MICROORGANISMS AND METHODS FOR ENHANCING THE AVAILABILITY OF REDUCING EQUIVALENTS IN THE PRESENCE OF METHANOL, FOR PRODUCING METHACRYLIC ACID
- Patent Title (中): 用于提高甲醇存在下生产甲基丙酸的减少等效物的可行性的微生物和方法
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Application No.: US15133150Application Date: 2016-04-19
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Publication No.: US20170073691A1Publication Date: 2017-03-16
- Inventor: Anthony P. BURGARD , Robin E. OSTERHOUT , Stephen J. VAN DIEN , Cara Ann TRACEWELL , Priti PHARKYA , Stefan ANDRAE
- Applicant: Genomatica, Inc.
- Main IPC: C12N15/52
- IPC: C12N15/52 ; C12N9/10 ; C12N9/06 ; C12P7/62 ; C12N9/04
Abstract:
Provided herein is a non-naturally occurring microbial organism having a methanol metabolic pathway that can enhance the availability of reducing equivalents in the presence of methanol. Such reducing equivalents can be used to increase the product yield of organic compounds produced by the microbial organism, such as 3-hydroxyisobutyrate or MAA. Also provided herein are methods for using such an organism to produce 3-hydroxyisobutyrate or MAA.
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