Invention Application
US20170073751A1 METHOD FOR SCREENING AGENTS PROMOTING SKIN BARRIER FUNCTION AND METHOD FOR EVALUATING SKIN BARRIER FUNCTION TAKING EPIDERMAL SERINE RACEMASE AND/OR D-SERINE LEVEL AS INDICATOR
审中-公开
用于筛选促进皮肤屏障功能的药剂的方法和用于评估作为指示剂的皮质骨架蛋白酶和/或D-丝氨酸蛋白酶的皮肤屏障功能的方法
- Patent Title: METHOD FOR SCREENING AGENTS PROMOTING SKIN BARRIER FUNCTION AND METHOD FOR EVALUATING SKIN BARRIER FUNCTION TAKING EPIDERMAL SERINE RACEMASE AND/OR D-SERINE LEVEL AS INDICATOR
- Patent Title (中): 用于筛选促进皮肤屏障功能的药剂的方法和用于评估作为指示剂的皮质骨架蛋白酶和/或D-丝氨酸蛋白酶的皮肤屏障功能的方法
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Application No.: US15123274Application Date: 2015-03-05
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Publication No.: US20170073751A1Publication Date: 2017-03-16
- Inventor: Yosuke TOJO , Masato IINO , Chieko MIZUMOTO , Yuzo YOSHIDA , Yuko MATSUURA , Hisashi MORI
- Applicant: Shiseido Company, Ltd
- Applicant Address: JP Chuo-ku, Tokyo
- Assignee: Shiseido Company, Ltd
- Current Assignee: Shiseido Company, Ltd
- Current Assignee Address: JP Chuo-ku, Tokyo
- Priority: JP2014-043073 20140305; JPPCT/JP2014/055680 20140305
- International Application: PCT/JP2015/056570 WO 20150305
- Main IPC: C12Q1/68
- IPC: C12Q1/68 ; A61Q19/00 ; A61K8/97 ; A61K8/64 ; G01N33/50 ; G01N33/68
Abstract:
The purpose of the present invention is to develop a method for screening drugs having the effect of increasing skin barrier function in in vitro studies and to evaluate barrier function in the skin. Candidate drugs can be screened by using the activity and/or expression level of serine racemase as an indicator.
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