- 专利标题： Guanine Analogs as Telomerase Substrates and Telomere Length Affectors
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申请号： US15419559申请日： 2017-01-30
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公开(公告)号： US20170233419A1公开(公告)日： 2017-08-17
- 发明人: Sergei M. Gryaznov , Ronald A. Pruzan , Krisztina Pongracz
- 申请人： Geron Corporation
- 主分类号： C07F9/6561
- IPC分类号： C07F9/6561
摘要：
This invention relates to compounds useful for inhibiting telomere elongation. More specifically, the invention provides nucleotide analogs that are incorporated into telomeres by telomerase thereby inhibiting elongation of telomeres. The compounds are use in treating cancer and other cell proliferative diseases.