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公开(公告)号：US20220306660A1
公开(公告)日：2022-09-29
申请号：US17686726
申请日：2022-03-04
申请人： Geron Corporation
IPC分类号： C07F9/6561 , C07D473/18
摘要： This invention relates to compounds useful for inhibiting telomere elongation. More specifically, the invention provides nucleotide analogs that are incorporated into telomeres by telomerase thereby inhibiting elongation of telomeres. The compounds are use in treating cancer and other cell proliferative diseases.
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公开(公告)号：US20170233419A1
公开(公告)日：2017-08-17
申请号：US15419559
申请日：2017-01-30
申请人： Geron Corporation
IPC分类号： C07F9/6561
CPC分类号： C07F9/65616 , C07D473/18
摘要： This invention relates to compounds useful for inhibiting telomere elongation. More specifically, the invention provides nucleotide analogs that are incorporated into telomeres by telomerase thereby inhibiting elongation of telomeres. The compounds are use in treating cancer and other cell proliferative diseases.
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3.发明授权公开(公告)号：US09593137B2
公开(公告)日：2017-03-14
申请号：US14366218
申请日：2012-12-21
申请人： Geron Corporation
IPC分类号： C07D473/18 , C07F9/6561
CPC分类号： C07F9/65616 , C07D473/18
摘要： This invention relates to compounds useful for inhibiting telomere elongation. More specifically, the invention provides nucleotide analogs that are incorporated into telomeres by telomerase thereby inhibiting elongation of telomeres. The compounds are useful in treating cancer and other cell proliferative diseases.
摘要翻译： 本发明涉及可用于抑制端粒伸长的化合物。 更具体地，本发明提供通过端粒酶掺入端粒中从而抑制端粒伸长的核苷酸类似物。 该化合物可用于治疗癌症和其他细胞增殖性疾病。
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公开(公告)号：US09388416B2
公开(公告)日：2016-07-12
申请号：US14720467
申请日：2015-05-22
申请人： Geron Corporation
IPC分类号： A61K31/7052 , C12N5/00 , C07H21/00 , C12N15/113 , A61K47/48 , C07H21/02 , C07H21/04 , C07C233/18
CPC分类号： C12N15/115 , A61K47/542 , A61K47/543 , A61K47/544 , A61K47/554 , C07C233/18 , C07H21/02 , C07H21/04 , C12N15/113 , C12N15/1137 , C12N2310/11 , C12N2310/113 , C12N2310/14 , C12N2310/31 , C12N2310/314 , C12N2310/351 , C12N2310/3515 , C12N2320/30 , C12Y207/07049
摘要： Compounds comprising an oligonucleotide moiety covalently linked to a lipid moiety are disclosed. The oligonucleotide moiety comprises a sequence that is complementary to the RNA component of human telomerase. The compounds inhibit telomerase activity in cells with a high potency and have superior cellular uptake characteristics.
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公开(公告)号：US09072790B2
公开(公告)日：2015-07-07
申请号：US13892065
申请日：2013-05-10
申请人： Geron Corporation
CPC分类号： A61K47/48092 , A61K47/549 , C07H21/00
摘要： Oligonucleotide conjugates, where an oligonucleotide is covalently attached to an aromatic system, are provided. In particular embodiments the oligonucleotide is complementary to the RNA component of human telomerase and is covalently attached to a nucleobase via an optional linker. The conjugates inhibit telomerase enzyme activity.
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公开(公告)号：US20200377543A1
公开(公告)日：2020-12-03
申请号：US16944903
申请日：2020-07-31
申请人： Geron Corporation
摘要： Orthogonally protected 3′-amino nucleoside monomers and efficient methods for their synthesis are described. The methods employ selective protection of the 3′-amino group in the presence of the unprotected nucleoside base.
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公开(公告)号：US20180119147A1
公开(公告)日：2018-05-03
申请号：US15786974
申请日：2017-10-18
申请人： Geron Corporation
IPC分类号： C12N15/113 , C12N15/11 , C07H21/00
CPC分类号： C12N15/113 , C07H21/00 , C12N15/111 , C12N15/1132 , C12N15/1137 , C12N15/1138 , C12N2310/14 , C12N2310/3145 , C12N2310/3515 , C12N2320/51
摘要： The present disclosure relates to RNA amidates and thioamidates useful for RNA interference applications. The RNA amidates and thioamidates contain at least one internucleoside linkage chosen from ribo-N3′→P5′ phosphoramidate (NP) and ribo-N3′→P5′ thiophosphoramidate (NPS) linkages, and optionally further containing at least one covalently conjugated lipid moiety. Compositions comprising the amidates and thioamidates are disclosed, as are methods for their use in modulating gene expression.
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公开(公告)号：US09572891B2
公开(公告)日：2017-02-21
申请号：US14728572
申请日：2015-06-02
申请人： Geron Corporation
IPC分类号： C07H21/00 , A61K31/7088 , A61K47/48
CPC分类号： A61K47/48092 , A61K47/549 , C07H21/00
摘要： Oligonucleotide conjugates, where an oligonucleotide is covalently attached to an aromatic system, are provided. In particular embodiments the oligonucleotide is complementary to the RNA component of human telomerase and is covalently attached to a nucleobase via an optional linker. The conjugates inhibit telomerase enzyme activity.
摘要翻译： 提供寡核苷酸共轭物，其中寡核苷酸共价连接到芳族体系上。 在具体实施方案中，寡核苷酸与人端粒酶的RNA组分互补，并通过任选的接头共价连接于核碱基。 缀合物抑制端粒酶的活性。
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公开(公告)号：US20160130580A1
公开(公告)日：2016-05-12
申请号：US14820364
申请日：2015-08-06
申请人： Geron Corporation
IPC分类号： C12N15/113
CPC分类号： C12N15/113 , C07H21/00 , C12N15/111 , C12N15/1132 , C12N15/1137 , C12N15/1138 , C12N2310/14 , C12N2310/3145 , C12N2310/3515 , C12N2320/51
摘要： The present disclosure relates to RNA amidates and thioamidates useful for RNA interference applications. The RNA amidates and thioamidates contain at least one internucleoside linkage chosen from ribo-N3′→P5′ phosphoramidate (NP) and ribo-N3′→P5′ thiophosphoramidate (NPS) linkages, and optionally further containing at least one covalently conjugated lipid moiety. Compositions comprising the amidates and thioamidates are disclosed, as are methods for their use in modulating gene expression.
摘要翻译： 本公开涉及可用于RNA干扰应用的RNA酰胺化物和硫代酰胺化物。 RNA酰胺化物和硫代酰胺酸盐含有至少一个选自核糖-N3'→P5'氨基磷酸酯（NP）和核糖-N3'→P5'硫代磷酰胺（NPS）键的核苷间键，并任选地还含有至少一个共价结合的脂质部分。 公开了包含酰胺化物和硫代酰胺酸盐的组合物，以及它们用于调节基因表达的方法。
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10.发明申请GUANINE ANALOGS AS TELOMERASE SUBSTRATES AND TELOMERE LENGTH AFFECTORS 有权作为TELOMERASE基板和TELOMERE长度影响的关键模拟公开(公告)号：US20150299232A1
公开(公告)日：2015-10-22
申请号：US14366218
申请日：2012-12-21
申请人： Geron Corporation
IPC分类号： C07F9/6561
CPC分类号： C07F9/65616 , C07D473/18
摘要： This invention relates to compounds useful for inhibiting telomere elongation. More specifically, the invention provides nucleotide analogs that are incorporated into telomeres by telomerase thereby inhibiting elongation of telomeres. The compounds are useful in treating cancer and other cell proliferative diseases.
摘要翻译： 本发明涉及可用于抑制端粒伸长的化合物。 更具体地，本发明提供通过端粒酶掺入端粒中从而抑制端粒伸长的核苷酸类似物。 该化合物可用于治疗癌症和其他细胞增殖性疾病。
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