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公开(公告)号：US20220306660A1
公开(公告)日：2022-09-29
申请号：US17686726
申请日：2022-03-04
申请人： Geron Corporation
IPC分类号： C07F9/6561 , C07D473/18
摘要： This invention relates to compounds useful for inhibiting telomere elongation. More specifically, the invention provides nucleotide analogs that are incorporated into telomeres by telomerase thereby inhibiting elongation of telomeres. The compounds are use in treating cancer and other cell proliferative diseases.
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公开(公告)号：US20170233419A1
公开(公告)日：2017-08-17
申请号：US15419559
申请日：2017-01-30
申请人： Geron Corporation
IPC分类号： C07F9/6561
CPC分类号： C07F9/65616 , C07D473/18
摘要： This invention relates to compounds useful for inhibiting telomere elongation. More specifically, the invention provides nucleotide analogs that are incorporated into telomeres by telomerase thereby inhibiting elongation of telomeres. The compounds are use in treating cancer and other cell proliferative diseases.
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3.发明授权公开(公告)号：US09593137B2
公开(公告)日：2017-03-14
申请号：US14366218
申请日：2012-12-21
申请人： Geron Corporation
IPC分类号： C07D473/18 , C07F9/6561
CPC分类号： C07F9/65616 , C07D473/18
摘要： This invention relates to compounds useful for inhibiting telomere elongation. More specifically, the invention provides nucleotide analogs that are incorporated into telomeres by telomerase thereby inhibiting elongation of telomeres. The compounds are useful in treating cancer and other cell proliferative diseases.
摘要翻译： 本发明涉及可用于抑制端粒伸长的化合物。 更具体地，本发明提供通过端粒酶掺入端粒中从而抑制端粒伸长的核苷酸类似物。 该化合物可用于治疗癌症和其他细胞增殖性疾病。
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公开(公告)号：US09072790B2
公开(公告)日：2015-07-07
申请号：US13892065
申请日：2013-05-10
申请人： Geron Corporation
CPC分类号： A61K47/48092 , A61K47/549 , C07H21/00
摘要： Oligonucleotide conjugates, where an oligonucleotide is covalently attached to an aromatic system, are provided. In particular embodiments the oligonucleotide is complementary to the RNA component of human telomerase and is covalently attached to a nucleobase via an optional linker. The conjugates inhibit telomerase enzyme activity.
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5.发明申请2'-ARABINO-FLUOROOLIGONUCLEOTIDE N3'-->P5' PHOSPHORAMIDATES: THEIR SYNTHESIS AND USE 有权2'-阿拉伯 - 氟代核糖核酸N3' - > P5'磷酰胺：其合成与使用公开(公告)号：US20150072345A1
公开(公告)日：2015-03-12
申请号：US14484049
申请日：2014-09-11
申请人： Geron Corporation
CPC分类号： C07H19/20 , C07H19/04 , C07H19/06 , C07H19/10 , C07H19/16 , C07H21/00 , C12N15/113 , C12N15/1137 , C12N2310/11 , C12Q1/6813 , C12Q1/6816 , C12Q1/6876 , C12Q2600/158 , C12Q2563/107 , C12Q2525/113
摘要： Oligonucleotides with a novel sugar-phosphate backbone containing at least one 2′-arabino-fluoronucleoside and an internucleoside 3′-NH—P(—O)(OR)—O-5′ linkage, where R is a positively charged counter ion or hydrogen, and methods of synthesizing and using the inventive oligonucleotides are provided. The inventive phosphoramidate 2′-arabino-fluorooligonucleotides have a high RNA binding affinity to complementary nucleic acids and are base and acid stable.
摘要翻译： 具有包含至少一个2'-阿拉伯 - 氟核苷和核苷间3'-NH-P（-O）（OR）-O-5'键的新型糖 - 磷酸骨架的寡核苷酸，其中R是带正电荷的抗衡离子或 氢，以及合成和使用本发明的寡核苷酸的方法。 本发明的氨基磷酸2'-阿拉伯 - 低聚核苷酸对互补核酸具有高的RNA结合亲和力，并且是碱和酸稳定的。
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公开(公告)号：US20240300992A1
公开(公告)日：2024-09-12
申请号：US18490328
申请日：2023-10-19
申请人： Geron Corporation
摘要： Orthogonally protected 3′-amino nucleoside monomers and efficient methods for their synthesis are described. The methods employ selective protection of the 3′-amino group in the presence of the unprotected nucleoside base.
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公开(公告)号：US20240034748A1
公开(公告)日：2024-02-01
申请号：US18074179
申请日：2022-12-02
申请人： Geron Corporation
摘要： Orthogonally protected 3′-amino nucleoside monomers and efficient methods for their synthesis are described. The methods employ selective protection of the 3′-amino group in the presence of the unprotected nucleoside base.
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公开(公告)号：US20200377543A1
公开(公告)日：2020-12-03
申请号：US16944903
申请日：2020-07-31
申请人： Geron Corporation
摘要： Orthogonally protected 3′-amino nucleoside monomers and efficient methods for their synthesis are described. The methods employ selective protection of the 3′-amino group in the presence of the unprotected nucleoside base.
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公开(公告)号：US20180127453A1
公开(公告)日：2018-05-10
申请号：US15678938
申请日：2017-08-16
申请人： Geron Corporation
IPC分类号： C07H19/20 , C12Q1/6876 , C12N15/113 , C07H19/04 , C07H21/00 , C07H19/06 , C07H19/10 , C12Q1/6816
CPC分类号： C07H21/00 , C07H19/04 , C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , C12N15/113 , C12N15/1137 , C12N2310/11 , C12Q1/6813 , C12Q1/6816 , C12Q1/6876 , C12Q2600/158 , C12Q2563/107 , C12Q2525/113
摘要： Oligonucleotides with a novel sugar-phosphate backbone containing at least one 2′-arabino-fluoronucleoside and an internucleoside 3′-NH—P(—O)(OR)—O-5′ linkage, where R is a positively charged counter ion or hydrogen, and methods of synthesizing and using the inventive oligonucleotides are provided. The inventive phosphoramidate 2′-arabino-fluorooligonucleotides have a high RNA binding affinity to complementary nucleic acids and are base and acid stable.
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公开(公告)号：US09572891B2
公开(公告)日：2017-02-21
申请号：US14728572
申请日：2015-06-02
申请人： Geron Corporation
IPC分类号： C07H21/00 , A61K31/7088 , A61K47/48
CPC分类号： A61K47/48092 , A61K47/549 , C07H21/00
摘要： Oligonucleotide conjugates, where an oligonucleotide is covalently attached to an aromatic system, are provided. In particular embodiments the oligonucleotide is complementary to the RNA component of human telomerase and is covalently attached to a nucleobase via an optional linker. The conjugates inhibit telomerase enzyme activity.
摘要翻译： 提供寡核苷酸共轭物，其中寡核苷酸共价连接到芳族体系上。 在具体实施方案中，寡核苷酸与人端粒酶的RNA组分互补，并通过任选的接头共价连接于核碱基。 缀合物抑制端粒酶的活性。
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