Invention Application
- Patent Title: CARM1 INHIBITORS AND USES THEREOF
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Application No.: US15648701Application Date: 2017-07-13
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Publication No.: US20170320883A1Publication Date: 2017-11-09
- Inventor: Richard CHESWORTH , Oscar Miguel MORADEI , Gideon SHAPIRO , Lei JIN , Robert E. BABINE
- Applicant: EPIZYME, INC.
- Main IPC: C07D487/10
- IPC: C07D487/10 ; C07D239/42 ; C07D495/04 ; C07D493/10 ; C07D493/04 ; C07D487/08 ; C07D487/04 ; C07D471/10 ; C07D471/04 ; C07D417/14 ; C07D413/14 ; C07D413/12 ; C07D413/04 ; C07D409/14 ; C07D405/14 ; C07D405/12 ; C07D405/04 ; C07D403/12 ; C07D403/04 ; C07D401/04 ; C07D498/04 ; C07D498/10
Abstract:
Provided herein are compounds of Formula (I): and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof; wherein X, R1, R1a, R2a, R2b, R2c, R2d, are as defined herein, and Ring HET is a 6-membered monocyclic heteroaryl ring system of Formula: wherein L2, R13, G8, G10, G11, and G12 are as defined herein. Compounds of the present invention are useful for inhibiting CARM1 activity. Methods of using the compounds for treating CARM1-mediated disorders are also described.
Public/Granted literature
- US09856267B2 CARM1 inhibitors and uses thereof Public/Granted day:2018-01-02
Information query
