公开(公告)号：US20170280720A1

公开(公告)日：2017-10-05

申请号：US15511514

申请日：2015-09-17

Applicant: EPIZYME, INC.

Inventor： Richard CHESWORTH ,  Lorna Helen MITCHELL ,  Gideon SHAPIRO ,  Oscar Miguel MORADEI ,  Kevin Wayne KUNTZ ,  Kenneth W. DUNCAN ,  Lei JIN

IPC: A01N47/10 ,  C07D277/20 ,  C07D233/54 ,  C07D209/10 ,  C07D241/02

CPC classification number: A01N47/10 ,  A61K38/45 ,  C07D209/10 ,  C07D233/54 ,  C07D241/02 ,  C07D277/20 ,  C07D471/04 ,  C07D487/04

Abstract: Described herein are compounds of Formula (I), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds described herein are useful for inhibiting arginine methyltransferase activity. Methods of using the compounds for treating arginine methyltransferase-mediated disorders are also described.

公开(公告)号：US20170320883A1

公开(公告)日：2017-11-09

申请号：US15648701

申请日：2017-07-13

Applicant: EPIZYME, INC.

Inventor： Richard CHESWORTH ,  Oscar Miguel MORADEI ,  Gideon SHAPIRO ,  Lei JIN ,  Robert E. BABINE

IPC: C07D487/10 ,  C07D239/42 ,  C07D495/04 ,  C07D493/10 ,  C07D493/04 ,  C07D487/08 ,  C07D487/04 ,  C07D471/10 ,  C07D471/04 ,  C07D417/14 ,  C07D413/14 ,  C07D413/12 ,  C07D413/04 ,  C07D409/14 ,  C07D405/14 ,  C07D405/12 ,  C07D405/04 ,  C07D403/12 ,  C07D403/04 ,  C07D401/04 ,  C07D498/04 ,  C07D498/10

CPC classification number: C07D487/10 ,  C07D239/42 ,  C07D401/04 ,  C07D403/04 ,  C07D403/12 ,  C07D405/04 ,  C07D405/12 ,  C07D405/14 ,  C07D409/14 ,  C07D413/04 ,  C07D413/12 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D471/10 ,  C07D487/04 ,  C07D487/08 ,  C07D493/04 ,  C07D493/10 ,  C07D495/04 ,  C07D498/04 ,  C07D498/10

Abstract: Provided herein are compounds of Formula (I): and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof; wherein X, R1, R1a, R2a, R2b, R2c, R2d, are as defined herein, and Ring HET is a 6-membered monocyclic heteroaryl ring system of Formula: wherein L2, R13, G8, G10, G11, and G12 are as defined herein. Compounds of the present invention are useful for inhibiting CARM1 activity. Methods of using the compounds for treating CARM1-mediated disorders are also described.

公开(公告)号：US20160039767A1

公开(公告)日：2016-02-11

申请号：US14775175

申请日：2014-03-14

Applicant: EPIZYME, INC.

Inventor： Lorna Helen MITCHELL ,  Gideon SHAPIRO ,  Richard CHESWORTH ,  Paula Ann BORIACK-SJODIN ,  Oscar Miguel MORADEI

IPC: C07D231/12

CPC classification number: C07D231/12 ,  C07D401/12

Abstract: Described herein are compounds of Formula (I), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds described herein are useful for inhibiting PRMT1 activity. Methods of using the compounds for treating PRMT1-mediated disorders are also described.

Abstract translation: 本文描述了式（I）的化合物，其药学上可接受的盐及其药物组合物。 本文所述的化合物可用于抑制PRMT1活性。 还描述了使用该化合物治疗PRMT1介导的病症的方法。