A system and method for payload management for a UAV/aircraft is disclosed. UAV/craft may be configured for a mission with aerodynamically-exposed payload to be delivered from originator to destination on a route in operating conditions. UAV/aircraft may provide an aerodynamic profile indicative of the expected aerodynamic performance in view of considerations such as flight characteristics and effects; a base aerodynamic profile without payload and a loaded aerodynamic profile with payload may be determined. The system and method may comprise estimation/determination and assessment/transaction of a freight charge for the mission based on aerodynamic profile and other considerations; freight charge may comprise a surcharge or penalty based on performance using unit reference points and factors/considerations. UAV/aircraft system can be configured and operated/managed to interface with the system; missions may be optimized based on freight charge or other considerations. The system comprises an interface with UAV/aircraft and data sources and/or networks for data communications.