- 专利标题: IRON PLATINUM PARTICLES FOR ADHERENCE OF BIOLOGICS ON MEDICAL IMPLANTS
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申请号: US15563398申请日: 2015-04-01
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公开(公告)号: US20180085459A1公开(公告)日: 2018-03-29
- 发明人: Tarek Fahmy , Albert Sinusas , Jung Seok Lee , Dongin Kim , Anthony Mathur , John Martin
- 申请人: Yale University , Magnus Flow Limited , University College London , Queen Mary University of London
- 国际申请: PCT/US2015/023880 WO 20150401
- 主分类号: A61K41/00
- IPC分类号: A61K41/00 ; A61L31/14 ; A61L31/10 ; A61L31/08 ; A61L31/06 ; A61L31/02 ; A61L27/58 ; A61L27/34 ; A61L27/30 ; A61L27/18 ; A61L27/06 ; A61L27/04 ; A61L27/02 ; A61K35/545 ; A61K35/44
摘要:
It has been discovered that iron-platinum ferromagnetic particles can be dispersed in a polymer and coated into or onto, or directly linked to or embedded on to, medical devices and magnetized. The magnetized devices are used to attract, capture, and/or retain magnetically labeled cells on the surface of the device in vivo. The magnetic particles have an iron/platinum core. Annealing the Fe/Pt particle is very important for introducing a L10 interior crystalline phase. The Fe:Pt molar ratio for creation of the crystal phase is important and a molar range of 1.2-3.0 Fe to Pt (molar precursors, i.e. starting compounds) is desired for magnetization. The magnetic force as a whole can be measured with a “Super Conducting Quantum Interference Device”, which is a sensitive magnetometer. The overall magnetic force is in the range from 0.1 to 2.0 Tesla.
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