Disclosed herein are systems and methods for isolating input/output computing resources. In some embodiments, a host device may include logic to identify a Process Address Space Identifier (PASID) for a process or container of the host device and logic to associate the PASID with an individual queue pair of a hardware device of the host device, wherein the queue pair includes two complementary queues and wherein the queue pair is owned by the process or container upon association with the PASID. Other embodiments may be disclosed and/or claimed.