- 专利标题： APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES
-
申请号： US15783993申请日： 2017-10-13
-
公开(公告)号： US20180251426A1公开(公告)日： 2018-09-06
- 发明人: Milan Bruncko , Yujia Dai , Hong Ding , George A. Doherty , Steven W. Elmore , Lisa Hasvold , Laura Hexamer , Aaron R. Kunzer , Robert A. Mantei , Chang H. Park , Cheol-Min Park , Andrew M. Petros , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Gary T. Wang , Le Wang , Xilu Wang , Michael D. Wendt , William J. McClellan
- 申请人： AbbVie, Inc.
- 主分类号： C07D209/08
- IPC分类号： C07D209/08 ; A61K31/635 ; C07D211/58 ; C07D401/12 ; C07D309/08 ; C07D471/04 ; C07D413/12 ; C07D405/14 ; C07D405/12 ; C07D403/12 ; C07D401/14 ; C07D309/04 ; C07D295/30 ; C07D277/24 ; C07D235/06 ; C07D231/56 ; C07D213/84 ; C07D213/74 ; C07D417/12
摘要：
Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.