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公开(公告)号：US20240199745A1
公开(公告)日：2024-06-20
申请号：US18349904
申请日：2023-07-10
Applicant: AbbVie Inc.
Inventor： Erwin R. Boghaert , Milan Bruncko , George Doherty , Robin R. Frey , Andrew S. Judd , Andrew C. Phillips , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao
CPC classification number: C07K16/2863 , A61K47/65 , A61K47/6803 , A61K47/6845 , A61K47/6849 , A61K47/6855 , A61K47/6857 , A61K47/6889 , A61P35/00 , A61K2039/505 , A61K2039/545 , A61K45/06 , C07K16/22 , C07K16/2827
Abstract: The invention relates to anti-Epidermal Growth Factor Receptor (EGFR) antibody drug conjugates (ADCs) which inhibit Bcl-xL, including compositions and methods of using said ADCs.
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公开(公告)号：US20210221789A1
公开(公告)日：2021-07-22
申请号：US17004841
申请日：2020-08-27
Inventor： Milan Bruncko , Hong Ding , George A. Doherty , Steven W. Elmore , Lisa A. Hasvold , Laura Hexamer , Aaron R. Kunzer , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Gary T. Wang , Le Wang , Xilu Wang , Michael D. Wendt , Robert Mantei , Todd M. Hansen
IPC: C07D401/12 , C07D401/14 , C07D519/00 , C07D471/04 , C07D209/82 , C07D403/12 , A61K31/496
Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
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3.发明申请公开(公告)号：US20200331907A1
公开(公告)日：2020-10-22
申请号：US16707777
申请日：2019-12-09
Applicant: AbbVie Inc.
Inventor： Zhi-Fu Tao , Xilu Wang , Michael Wendt , Andrew Souers , Andrew Judd , Aaron Kunzer , Gerard Sullivan
IPC: C07D471/04 , A61K31/5377 , A61K31/496 , A61K45/06 , A61P37/00 , A61P35/00
Abstract: Disclosed herein are compounds that inhibit the activity of anti-apoptotic Bc1-2 proteins, compositions containing the compounds and methods of treating diseases using the compounds.
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公开(公告)号：US20200325153A1
公开(公告)日：2020-10-15
申请号：US16872279
申请日：2020-05-11
Applicant: AbbVie Inc. , AbbVie Deutschland GmbH & Co. KG
Inventor： Andrew S. Judd , Aaron R. Kunzer , Chunqiu Lai , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Jesse A. Teske , Anthony Mastracchio , Xilu Wang , Cheng Ji , Michael D. Wendt , Xiaohong Song , George A. Doherty , Katja Jantos , Wilfried Braje , Andreas Kling , Frauke Pohlki , Thomas D. Penning
IPC: C07D495/16 , C07D495/18 , A61K45/06 , C07D495/22 , C07D491/18 , A61K31/519 , C07D491/22 , A61P35/00 , A61P35/02
Abstract: The present disclosure provides for compounds of formula (I) wherein A2, A3, A4, A6, A7, A8, A15, RA, R5, R9, R10A, R10B, R11, R12, R13, R14, R16, W, X, and Y have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including cancer. Also provided are pharmaceutical compositions comprising compounds of formula (I).
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5.发明申请公开(公告)号：US20200253954A1
公开(公告)日：2020-08-13
申请号：US16578229
申请日：2019-09-20
Applicant: AbbVie Inc.
Inventor： Le Wang , George Doherty , Xilu Wang , Zhi-Fu Tao , Milan Bruncko , Aaron R. Kunzer , Michael D. Wendt , Xiaohong Song , Robin Frey , Todd M. Hansen , Gerard M. Sullivan , Andrew Judd , Andrew Souers
IPC: A61K31/4725 , A61K31/541 , A61K31/5377 , A61K31/5025 , A61K31/4985 , C07D513/04 , C07D493/08 , C07D487/04 , C07D471/04 , C07D417/14 , C07D401/04
Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-xL protein.
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Patent Agency Ranking
6.发明申请公开(公告)号：US20200231566A1
公开(公告)日：2020-07-23
申请号：US16557819
申请日：2019-08-30
Inventor： Milan Bruncko , Hong Ding , George A. Doherty , Steven W. Elmore , Lisa A. Hasvold , Laura Hexamer , Aaron R. Kunzer , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Gary T. Wang , Le Wang , Xilu Wang , Michael D. Wendt , Robert Mantei , Todd M. Hansen
IPC: C07D401/12 , A61K31/496 , C07D403/12 , C07D209/82 , C07D471/04 , C07D519/00 , C07D401/14
Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
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公开(公告)号：US20190144465A1
公开(公告)日：2019-05-16
申请号：US15998789
申请日：2018-08-15
Applicant: AbbVie Inc. , AbbVie Deutschland GmbH & Co. KG
Inventor： Andrew S. Judd , Aaron R. Kunzer , Chunqiu Lai , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Jesse A. Teske , Anthony Mastracchio , Xilu Wang , Cheng Ji , Michael D. Wendt , Xiaohong Song , George A. Doherty , Katja Jantos , Wilfried Braje , Andreas Kling , Frauke Pohlki , Thomas D. Penning
IPC: C07D495/16 , A61P35/02
Abstract: The present disclosure provides for compounds of formula (I) wherein A2, A3, A4, A6, A7, A8, R15, RA, R5, R9, R10A, R10B, R11, R12, R13, R14, R16, W, X, and Y have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including cancer. Also provided are pharmaceutical compositions comprising compounds of formula (I).
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公开(公告)号：US20170296531A9
公开(公告)日：2017-10-19
申请号：US14961748
申请日：2015-12-07
Applicant: AbbVie Inc.
Inventor： Le Wang , George Doherty , Xilu Wang , Zhi-Fu Tao , Milan Bruncko , Aaron R. Kunzer , Michael D. Wendt , Xiaohong Song , Robin Frey , Todd M. Hansen , Gerard M. Sullivan , Andrew Judd , Andrew J. Souers
IPC: A61K31/4725 , C07D493/08 , C07D487/04 , C07D417/14 , C07D401/04 , A61K31/541 , A61K31/5377 , A61K31/5025 , A61K31/4985 , C07D513/04 , C07D471/04
CPC classification number: A61K31/4725 , A61K31/4985 , A61K31/5025 , A61K31/5377 , A61K31/541 , C07D401/04 , C07D417/14 , C07D471/04 , C07D487/04 , C07D493/08 , C07D513/04
Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-xL protein.
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公开(公告)号：US09650358B2
公开(公告)日：2017-05-16
申请号：US14207854
申请日：2014-03-13
Applicant: AbbVie Inc.
Inventor： Anthony Mastracchio , Milan Bruncko , Chunqiu Lai , Julie M. Miyashiro , Zhi-Fu Tao , Keith W. Woods , Thomas D. Penning , Andrew J. Souers
IPC: C07D401/04 , C07D401/14 , C07D405/14 , C07D409/14 , C07D417/14 , C07D453/02 , C07D471/04 , A61K31/4545 , A61K31/4439 , A61K31/5377 , A61K31/444 , A61K31/506 , A61K31/439
CPC classification number: C07D401/04 , A61K31/439 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/506 , A61K31/5377 , C07D401/14 , C07D405/14 , C07D409/14 , C07D417/14 , C07D453/02 , C07D471/04
Abstract: Disclosed are compound of Formula (Ia), wherein R2, R12, R16, J, Q, X, Y and Z are as defined in the specification, and pharmaceutically acceptable salts thereof. The compounds may be used as agents in the treatment of diseases, including cancer. Also provided are pharmaceutical compositions comprising one or more compounds of Formula (Ia).
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10.发明申请公开(公告)号：US20160158218A1
公开(公告)日：2016-06-09
申请号：US14961748
申请日：2015-12-07
Applicant: AbbVie Inc.
Inventor： Le Wang , George Doherty , Xilu Wang , Zhi-Fu Tao , Milan Bruncko , Aaron R. Kunzer , Michael D. Wendt , Xiaohong Song , Robin Frey , Todd M. Hansen , Gerard M. Sullivan , Andrew Judd , Andrew J. Souers
IPC: A61K31/4725 , A61K31/5025 , A61K31/4985 , A61K31/5377 , A61K31/541
CPC classification number: A61K31/4725 , A61K31/4985 , A61K31/5025 , A61K31/5377 , A61K31/541 , C07D401/04 , C07D417/14 , C07D471/04 , C07D487/04 , C07D493/08 , C07D513/04
Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-xL protein.
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