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公开(公告)号：US20240199745A1
公开(公告)日：2024-06-20
申请号：US18349904
申请日：2023-07-10
申请人： AbbVie Inc.
发明人： Erwin R. Boghaert , Milan Bruncko , George Doherty , Robin R. Frey , Andrew S. Judd , Andrew C. Phillips , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao
CPC分类号： C07K16/2863 , A61K47/65 , A61K47/6803 , A61K47/6845 , A61K47/6849 , A61K47/6855 , A61K47/6857 , A61K47/6889 , A61P35/00 , A61K2039/505 , A61K2039/545 , A61K45/06 , C07K16/22 , C07K16/2827
摘要： The invention relates to anti-Epidermal Growth Factor Receptor (EGFR) antibody drug conjugates (ADCs) which inhibit Bcl-xL, including compositions and methods of using said ADCs.
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公开(公告)号：US20210221789A1
公开(公告)日：2021-07-22
申请号：US17004841
申请日：2020-08-27
发明人： Milan Bruncko , Hong Ding , George A. Doherty , Steven W. Elmore , Lisa A. Hasvold , Laura Hexamer , Aaron R. Kunzer , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Gary T. Wang , Le Wang , Xilu Wang , Michael D. Wendt , Robert Mantei , Todd M. Hansen
IPC分类号： C07D401/12 , C07D401/14 , C07D519/00 , C07D471/04 , C07D209/82 , C07D403/12 , A61K31/496
摘要： Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
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公开(公告)号：US20200325153A1
公开(公告)日：2020-10-15
申请号：US16872279
申请日：2020-05-11
发明人： Andrew S. Judd , Aaron R. Kunzer , Chunqiu Lai , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Jesse A. Teske , Anthony Mastracchio , Xilu Wang , Cheng Ji , Michael D. Wendt , Xiaohong Song , George A. Doherty , Katja Jantos , Wilfried Braje , Andreas Kling , Frauke Pohlki , Thomas D. Penning
IPC分类号： C07D495/16 , C07D495/18 , A61K45/06 , C07D495/22 , C07D491/18 , A61K31/519 , C07D491/22 , A61P35/00 , A61P35/02
摘要： The present disclosure provides for compounds of formula (I) wherein A2, A3, A4, A6, A7, A8, A15, RA, R5, R9, R10A, R10B, R11, R12, R13, R14, R16, W, X, and Y have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including cancer. Also provided are pharmaceutical compositions comprising compounds of formula (I).
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4.发明申请公开(公告)号：US20200231566A1
公开(公告)日：2020-07-23
申请号：US16557819
申请日：2019-08-30
发明人： Milan Bruncko , Hong Ding , George A. Doherty , Steven W. Elmore , Lisa A. Hasvold , Laura Hexamer , Aaron R. Kunzer , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Gary T. Wang , Le Wang , Xilu Wang , Michael D. Wendt , Robert Mantei , Todd M. Hansen
IPC分类号： C07D401/12 , A61K31/496 , C07D403/12 , C07D209/82 , C07D471/04 , C07D519/00 , C07D401/14
摘要： Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
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公开(公告)号：US20190144465A1
公开(公告)日：2019-05-16
申请号：US15998789
申请日：2018-08-15
发明人： Andrew S. Judd , Aaron R. Kunzer , Chunqiu Lai , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Jesse A. Teske , Anthony Mastracchio , Xilu Wang , Cheng Ji , Michael D. Wendt , Xiaohong Song , George A. Doherty , Katja Jantos , Wilfried Braje , Andreas Kling , Frauke Pohlki , Thomas D. Penning
IPC分类号： C07D495/16 , A61P35/02
摘要： The present disclosure provides for compounds of formula (I) wherein A2, A3, A4, A6, A7, A8, R15, RA, R5, R9, R10A, R10B, R11, R12, R13, R14, R16, W, X, and Y have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including cancer. Also provided are pharmaceutical compositions comprising compounds of formula (I).
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公开(公告)号：US20170296531A9
公开(公告)日：2017-10-19
申请号：US14961748
申请日：2015-12-07
申请人： AbbVie Inc.
发明人： Le Wang , George Doherty , Xilu Wang , Zhi-Fu Tao , Milan Bruncko , Aaron R. Kunzer , Michael D. Wendt , Xiaohong Song , Robin Frey , Todd M. Hansen , Gerard M. Sullivan , Andrew Judd , Andrew J. Souers
IPC分类号： A61K31/4725 , C07D493/08 , C07D487/04 , C07D417/14 , C07D401/04 , A61K31/541 , A61K31/5377 , A61K31/5025 , A61K31/4985 , C07D513/04 , C07D471/04
CPC分类号： A61K31/4725 , A61K31/4985 , A61K31/5025 , A61K31/5377 , A61K31/541 , C07D401/04 , C07D417/14 , C07D471/04 , C07D487/04 , C07D493/08 , C07D513/04
摘要： Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-xL protein.
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公开(公告)号：US09650358B2
公开(公告)日：2017-05-16
申请号：US14207854
申请日：2014-03-13
申请人： AbbVie Inc.
发明人： Anthony Mastracchio , Milan Bruncko , Chunqiu Lai , Julie M. Miyashiro , Zhi-Fu Tao , Keith W. Woods , Thomas D. Penning , Andrew J. Souers
IPC分类号： C07D401/04 , C07D401/14 , C07D405/14 , C07D409/14 , C07D417/14 , C07D453/02 , C07D471/04 , A61K31/4545 , A61K31/4439 , A61K31/5377 , A61K31/444 , A61K31/506 , A61K31/439
CPC分类号： C07D401/04 , A61K31/439 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/506 , A61K31/5377 , C07D401/14 , C07D405/14 , C07D409/14 , C07D417/14 , C07D453/02 , C07D471/04
摘要： Disclosed are compound of Formula (Ia), wherein R2, R12, R16, J, Q, X, Y and Z are as defined in the specification, and pharmaceutically acceptable salts thereof. The compounds may be used as agents in the treatment of diseases, including cancer. Also provided are pharmaceutical compositions comprising one or more compounds of Formula (Ia).
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公开(公告)号：US20160158218A1
公开(公告)日：2016-06-09
申请号：US14961748
申请日：2015-12-07
申请人： AbbVie Inc.
发明人： Le Wang , George Doherty , Xilu Wang , Zhi-Fu Tao , Milan Bruncko , Aaron R. Kunzer , Michael D. Wendt , Xiaohong Song , Robin Frey , Todd M. Hansen , Gerard M. Sullivan , Andrew Judd , Andrew J. Souers
IPC分类号： A61K31/4725 , A61K31/5025 , A61K31/4985 , A61K31/5377 , A61K31/541
CPC分类号： A61K31/4725 , A61K31/4985 , A61K31/5025 , A61K31/5377 , A61K31/541 , C07D401/04 , C07D417/14 , C07D471/04 , C07D487/04 , C07D493/08 , C07D513/04
摘要： Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-xL protein.
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9.发明授权公开(公告)号：US09315488B2
公开(公告)日：2016-04-19
申请号：US14726337
申请日：2015-05-29
申请人： AbbVie Inc.
发明人： Hong Ding , Steven W. Elmore , Lisa Hasvold , Laura A. Hexamer , Aaron R. Kunzer , William J. McClellan , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Michael D. Wendt
IPC分类号： C07D295/155 , C07D209/08 , C07D211/58 , C07D401/12 , C07D309/04
CPC分类号： C07D401/12 , A61K31/407 , A61K31/495 , A61K31/496 , A61K31/501 , A61K31/5377 , A61K45/06 , C07D209/08 , C07D209/32 , C07D211/58 , C07D211/96 , C07D213/64 , C07D215/20 , C07D217/16 , C07D231/56 , C07D235/26 , C07D241/04 , C07D249/04 , C07D295/125 , C07D295/14 , C07D295/155 , C07D309/04 , C07D309/14 , C07D401/06 , C07D403/06 , C07D405/06 , C07D405/12 , C07D405/14 , C07D413/06 , C07D417/12 , C07D471/04 , C07D487/04
摘要： Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 or Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which are expressed anti-apoptotic Bcl-2 protein.
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10.发明授权公开(公告)号：US09045420B2
公开(公告)日：2015-06-02
申请号：US14081940
申请日：2013-11-15
申请人： AbbVie Inc.
发明人： George A. Doherty , Steven W. Elmore , Lisa Hasvold , Laura A. Hexamer , Robert A. Mantei , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Gary T. Wang , Le Wang , Xilu Wang , Michael D. Wendt , Todd M. Hansen
IPC分类号： A61K31/416 , C07D403/14 , C07D413/14 , C07D215/14 , C07D209/32 , C07D211/96 , C07D213/64 , C07D215/20 , C07D217/16 , C07D231/56 , C07D235/26 , C07D249/04 , C07D295/125 , C07D295/14 , C07D309/14 , C07D401/12 , C07D405/12 , C07D417/12 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D295/13 , C07D309/08 , C07D487/04 , C07D209/20 , C07D295/155 , C07D309/32
CPC分类号： C07D215/14 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D209/20 , C07D209/32 , C07D211/96 , C07D213/64 , C07D215/20 , C07D217/16 , C07D231/56 , C07D235/26 , C07D249/04 , C07D295/125 , C07D295/13 , C07D295/14 , C07D295/155 , C07D309/08 , C07D309/14 , C07D309/32 , C07D401/12 , C07D405/12 , C07D417/12 , C07D487/04
摘要： Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 or Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which are expressed anti-apoptotic Bcl-2 protein.
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