- 专利标题： NOVEL THIOUREA DERIVATIVES AS ACTIVATORS OF RORalpha AND PHARMACEUTICAL COMPOSITION CONTAINING SAME
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申请号： US15759588申请日： 2012-05-23
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公开(公告)号： US20180265462A1公开(公告)日： 2018-09-20
- 发明人: Mi Ock LEE , Hyeung Geun PARK , Eun Jin KIM , Ho Young SON , Hyo Jun JUNG , Suck Chang HONG , Tae Young NA
- 申请人： Mi Ock LEE , Hyeung Geun PARK , Eun Jin KIM , Ho Young SON , Hyo Jun JUNG , Suck Chang HONG , Tae Young NA
- 申请人地址： KR Seoul
- 专利权人： SEOUL NATIONAL UNIVERSITY R & DB FOUNDATION
- 当前专利权人： SEOUL NATIONAL UNIVERSITY R & DB FOUNDATION
- 当前专利权人地址： KR Seoul
- 优先权： KR10-2011-0048455 20110523; KR10-2011-0128903 20111205; KR10-2012-0054540 20120523
- 国际申请： PCT/KR2012/004081 WO 20120523
- 主分类号： C07C335/12
- IPC分类号： C07C335/12 ; A61P29/00 ; A61P3/06 ; A61P1/16 ; A61P9/10
摘要：
Provided is a compound activating RORα gene, particularly a JC1 compound containing CGP52608 thiazolidinedione as a lead substance, and a pharmaceutically acceptable salt thereof. The compound is a lipid accumulation inhibitor and applicable to the treatment of metabolic diseases or inflammatory diseases.
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