Systems, methods, and apparatus for a slave-to-slave communication over a serial communication link are provided. An apparatus includes an interface adapted to couple the apparatus to a serial bus, and a processing circuit. The processing circuit may be configured to receive a request for a slave-to-slave transaction while servicing an in-band interrupt detected on a serial bus, the request for the slave-to-slave transaction indicating a source address and a target address, generate a first frame that includes the source address, the target address and a command code configured to initiate the slave-to-slave transaction between the source slave device and at least one target slave device, and initiate a data transfer on the serial bus between the source slave device and the at least one target slave device by transmitting the first frame on the serial bus.