- 专利标题： RECOMBINANT HCMV AND RHCMV VECTORS AND USES THEREOF
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申请号： US15965246申请日： 2018-04-27
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公开(公告)号： US20190099479A1公开(公告)日： 2019-04-04
- 发明人: Louis Picker , Jay A. Nelson , Klaus Frueh , Michael A. Jarvis , scott G. Hansen
- 申请人： Oregon Health & Science University
- 主分类号： A61K39/12
- IPC分类号： A61K39/12 ; C12N15/86 ; A61K39/00 ; A61K39/21 ; A61K39/275 ; A61K39/145 ; A61K39/13 ; A61K39/08 ; C12N7/00 ; C12N15/869 ; C07K14/045 ; C07K14/005 ; C07K14/16
摘要：
The present disclosure relates to recombinant rhesus cytomegalovirus (RhCMV) and human cytomegalovirus (HCMV) vectors encoding heterologous antigens, such as pathogen-specific antigens or tumor antigens, which may be used, for example, for the treatment or prevention of infectious disease or cancer. The recombinant RhCMV or HCMV vectors elicit and maintain high level cellular immune responses specific for the heterologous antigen while including deletions in one or more genes essential or augmenting for CMV replication, dissemination or spread.
公开/授权文献
- US11266732B2 Recombinant HCMV and RHCMV vectors and uses thereof 公开/授权日：2022-03-08
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