公开(公告)号：US20190099479A1

公开(公告)日：2019-04-04

申请号：US15965246

申请日：2018-04-27

申请人： Oregon Health & Science University

发明人： Louis Picker ,  Jay A. Nelson ,  Klaus Frueh ,  Michael A. Jarvis ,  scott G. Hansen

IPC分类号： A61K39/12 ,  C12N15/86 ,  A61K39/00 ,  A61K39/21 ,  A61K39/275 ,  A61K39/145 ,  A61K39/13 ,  A61K39/08 ,  C12N7/00 ,  C12N15/869 ,  C07K14/045 ,  C07K14/005 ,  C07K14/16

摘要： The present disclosure relates to recombinant rhesus cytomegalovirus (RhCMV) and human cytomegalovirus (HCMV) vectors encoding heterologous antigens, such as pathogen-specific antigens or tumor antigens, which may be used, for example, for the treatment or prevention of infectious disease or cancer. The recombinant RhCMV or HCMV vectors elicit and maintain high level cellular immune responses specific for the heterologous antigen while including deletions in one or more genes essential or augmenting for CMV replication, dissemination or spread.