发明申请
- 专利标题: QUINOLONE COMPOUND
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申请号: US16659987申请日: 2019-10-22
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公开(公告)号: US20200055823A1公开(公告)日: 2020-02-20
- 发明人: Mamuti ABUDUSAIMI , Fangguo YE , Jiangqin SUN , Hisashi MIYAMOTO , Jay-Fei CHENG , Daisuke OKA
- 申请人: OTSUKA PHARMACEUTICAL CO., LTD.
- 优先权: CNPCT/CN2011/001477 20110831; CNPCT/CN2012/001044 20120806
- 主分类号: C07D215/56
- IPC分类号: C07D215/56 ; C07D519/00 ; C07D413/12 ; C07D498/06 ; C07D417/04 ; C07D405/04 ; C07D401/14 ; C07D401/04 ; C07D498/04 ; C07D487/04 ; C07D413/14 ; C07D413/04 ; C07D409/14 ; C07D409/04 ; C07D401/10 ; C07D471/04
摘要:
The present invention provides a compound represented by the formula (I) wherein X is a hydrogen atom or a fluorine atom; R is a hydrogen atom or alkyl; R1 is (1) cyclopropyl optionally substituted by 1 to 3 halogen atoms or (2) phenyl optionally substituted by 1 to 3 halogen atoms; R2 is alkyl, alkoxy, haloalkoxy, a halogen atom, cyano, etc.; and R3 is 7-oxo-7,8-dihydro-1,8-naphthyridinyl, 3-pyridyl, etc., or a salt thereof. The compound of the present invention has excellent antimicrobial activity against Clostridium difficile and is useful for the prevention or treatment of intestinal infection such as Clostridium difficile-associated diarrhea.
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