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公开(公告)号：US20150005287A2
公开(公告)日：2015-01-01
申请号：US14193656
申请日：2014-02-28
发明人： Mamuti ABUDUSAIMI , Fangguo YE , Jiangqin SUN , Hisashi MIYAMOTO , Jay-Fei CHENG , Daisuke OKA
IPC分类号： C07D215/56 , C07D401/04 , C07D417/04 , C07D405/04 , C07D401/14 , C07D471/04 , C07D498/06
CPC分类号： C07D215/56 , C07D401/04 , C07D401/10 , C07D401/14 , C07D405/04 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D471/04 , C07D487/04 , C07D498/04 , C07D498/06 , C07D519/00
摘要： The present invention provides a compound represented by the formula (I) wherein X is a hydrogen atom or a fluorine atom; R is a hydrogen atom or alkyl; R1 is (1) cyclopropyl optionally substituted by to 3 halogen atoms or (2) phenyl optionally substituted by 1 to 3 halogen atoms; R2 is alkyl, alkoxy, haloalkoxy, a halogen atom, cyano, etc.; and R3 is 7-oxo-7,8-dihydro-1,8-naphthyridinyl, 3-pyridyl, etc., or a salt thereof. The compound of the present invention has excellent antimicrobial activity against Clostridium difficile and is useful for the prevention or treatment of intestinal infection such as Clostridium difficile-associated diarrhea.
摘要翻译： 本发明提供由式（I）表示的化合物，其中X为氢原子或氟原子; R是氢原子或烷基; R 1为（1）任选被3个卤素原子取代的环丙基或（2）任选被1至3个卤素原子取代的苯基; R2是烷基，烷氧基，卤代烷氧基，卤原子，氰基等; R3为7-氧代-7,8-二氢-1,8-二氮杂环丁烷基，3-吡啶基等，或其盐。 本发明的化合物对艰难梭菌具有优异的抗微生物活性，可用于预防或治疗肠道感染如难辨梭状芽孢杆菌相关性腹泻。
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公开(公告)号：US20170362180A1
公开(公告)日：2017-12-21
申请号：US15691216
申请日：2017-08-30
发明人： Mamuti ABUDUSAIMI , Fangguo YE , Jiangqin SUN , Hisashi MIYAMOTO , Jay-Fei CHENG , Daisuke OKA
IPC分类号： C07D215/56 , C07D401/04 , C07D498/04 , C07D487/04 , C07D471/04 , C07D417/04 , C07D413/14 , C07D413/12 , C07D413/04 , C07D409/14 , C07D409/04 , C07D405/04 , C07D401/14 , C07D401/10 , C07D498/06 , C07D519/00
CPC分类号： C07D215/56 , C07D401/04 , C07D401/10 , C07D401/14 , C07D405/04 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D471/04 , C07D487/04 , C07D498/04 , C07D498/06 , C07D519/00
摘要： The present invention provides a compound represented by the formula (I) wherein X is a hydrogen atom or a fluorine atom; R is a hydrogen atom or alkyl; R1 is (1) cyclopropyl optionally substituted by 1 to 3 halogen atoms or (2) phenyl optionally substituted by 1 to 3 halogen atoms; R2 is alkyl, alkoxy, haloalkoxy, a halogen atom, cyano, etc.; and R3 is 7-oxo-7,8-dihydro-1,8-naphthyridinyl, 3-pyridyl, etc., or a salt thereof. The compound of the present invention has excellent antimicrobial activity against Clostridium difficile and is useful for the prevention or treatment of intestinal infection such as Clostridium difficile-associated diarrhea.
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公开(公告)号：US20160340314A1
公开(公告)日：2016-11-24
申请号：US15225130
申请日：2016-08-01
发明人： Mamuti ABUDUSAIMI , Fangguo YE , Jiangqin SUN , Hisashi MIYAMOTO , Jay-Fei CHENG , Daisuke OKA
IPC分类号： C07D215/56 , C07D401/04 , C07D498/06 , C07D405/04 , C07D519/00 , C07D413/14 , C07D417/04 , C07D413/12 , C07D409/04 , C07D401/14 , C07D409/14 , C07D471/04 , C07D487/04
CPC分类号： C07D215/56 , C07D401/04 , C07D401/10 , C07D401/14 , C07D405/04 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D471/04 , C07D487/04 , C07D498/04 , C07D498/06 , C07D519/00
摘要： The present invention provides a compound represented by the formula (I) wherein X is a hydrogen atom or a fluorine atom; R is a hydrogen atom or alkyl; R1 is (1) cyclopropyl optionally substituted by 1 to 3 halogen atoms or (2) phenyl optionally substituted by 1 to 3 halogen atoms; R2 is alkyl, alkoxy, haloalkoxy, a halogen atom, cyano, etc.; and R3 is 7-oxo-7,8-dihydro-1,8-naphthyridinyl, 3-pyridyl, etc., or a salt thereof. The compound of the present invention has excellent antimicrobial activity against Clostridium difficile and is useful for the prevention or treatment of intestinal infection such as Clostridium difficile-associated diarrhea.
摘要翻译： 其中X是氢原子或氟原子; R是氢原子或烷基; R1是（1）任选被1至3个卤素原子取代的环丙基或（2）任选被1至3个卤素原子取代的苯基; R2是烷基，烷氧基，卤代烷氧基，卤原子，氰基等; R3为7-氧代-7,8-二氢-1,8-二氮杂环丁烷基，3-吡啶基等，或其盐。 本发明的化合物对艰难梭菌具有优异的抗微生物活性，可用于预防或治疗肠道感染如难辨梭状芽孢杆菌相关性腹泻。
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公开(公告)号：US20210032207A1
公开(公告)日：2021-02-04
申请号：US17073513
申请日：2020-10-19
发明人： Mamuti ABUDUSAIMI , Fangguo YE , Jiangqin SUN , Hisashi MIYAMOTO , Jay-Fei CHENG , Daisuke OKA
IPC分类号： C07D215/56 , C07D471/04 , C07D401/10 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/14 , C07D487/04 , C07D498/04 , C07D401/04 , C07D401/14 , C07D405/04 , C07D417/04 , C07D498/06 , C07D413/12 , C07D519/00
摘要： The present invention provides a compound represented by the formula (T) wherein X is a hydrogen atom or a fluorine atom; R is a hydrogen atom or alkyl; R1 is (1) cyclopropyl optionally substituted by 1 to 3 halogen atoms or (2) phenyl optionally substituted by 1 to 3 halogen atoms; R2 is alkyl, alkoxy, haloalkoxy, a halogen atom, cyano, etc.; and R3 is 7-oxo-7,8-dihydro-1,8-naphthyridinyl, 3-pyridyl, etc., or a salt thereof. The compound of the present invention has excellent antimicrobial activity against Clostridium difficile and is useful for the prevention or treatment of intestinal infection such as Clostridium difficile-associated diarrhea.
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公开(公告)号：US20190077762A1
公开(公告)日：2019-03-14
申请号：US16185437
申请日：2018-11-09
发明人： Mamuti ABUDUSAIMI , Fangguo YE , Jiangqin SUN , Hisashi MIYAMOTO , Jay-Fei CHENG , Daisuke OKA
IPC分类号： C07D215/56 , C07D519/00 , C07D471/04 , C07D401/04 , C07D409/04 , C07D498/04 , C07D401/10 , C07D401/14 , C07D405/04 , C07D498/06 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D487/04 , C07D413/12
摘要： The present invention provides a compound represented by the formula (I) wherein X is a hydrogen atom or a fluorine atom; R is a hydrogen atom or alkyl; R1 is (1) cyclopropyl optionally substituted by 1 to 3 halogen atoms or (2) phenyl optionally substituted by 1 to 3 halogen atoms; R2 is alkyl, alkoxy, haloalkoxy, a halogen atom, cyano, etc.; and R3 is 7-oxo-7,8-dihydro-1,8-naphthyridinyl, 3-pyridyl, etc., or a salt thereof. The compound of the present invention has excellent, antimicrobial activity against Clostridium difficile and is useful for the prevention or treatment of intestinal infection such as Clostridium difficile-associated diarrhea.
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公开(公告)号：US20200055823A1
公开(公告)日：2020-02-20
申请号：US16659987
申请日：2019-10-22
发明人： Mamuti ABUDUSAIMI , Fangguo YE , Jiangqin SUN , Hisashi MIYAMOTO , Jay-Fei CHENG , Daisuke OKA
IPC分类号： C07D215/56 , C07D519/00 , C07D413/12 , C07D498/06 , C07D417/04 , C07D405/04 , C07D401/14 , C07D401/04 , C07D498/04 , C07D487/04 , C07D413/14 , C07D413/04 , C07D409/14 , C07D409/04 , C07D401/10 , C07D471/04
摘要： The present invention provides a compound represented by the formula (I) wherein X is a hydrogen atom or a fluorine atom; R is a hydrogen atom or alkyl; R1 is (1) cyclopropyl optionally substituted by 1 to 3 halogen atoms or (2) phenyl optionally substituted by 1 to 3 halogen atoms; R2 is alkyl, alkoxy, haloalkoxy, a halogen atom, cyano, etc.; and R3 is 7-oxo-7,8-dihydro-1,8-naphthyridinyl, 3-pyridyl, etc., or a salt thereof. The compound of the present invention has excellent antimicrobial activity against Clostridium difficile and is useful for the prevention or treatment of intestinal infection such as Clostridium difficile-associated diarrhea.
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公开(公告)号：US20140179675A1
公开(公告)日：2014-06-26
申请号：US14193656
申请日：2014-02-28
发明人： Mamuti ABUDUSAIMI , Fangguo YE , Jiangqin SUN , Hisashi MIYAMOTO , Jay-Fei CHENG , Daisuke OKA
IPC分类号： C07D215/56 , C07D401/04 , C07D417/04 , C07D405/04 , C07D401/14 , C07D471/04 , C07D498/06
CPC分类号： C07D215/56 , C07D401/04 , C07D401/10 , C07D401/14 , C07D405/04 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D471/04 , C07D487/04 , C07D498/04 , C07D498/06 , C07D519/00
摘要： The present invention provides a compound represented by the formula (I) wherein X is a hydrogen atom or a fluorine atom; R is a hydrogen atom or alkyl; R1 is (1) cyclopropyl optionally substituted by 1 to 3 halogen atoms or (2) phenyl optionally substituted by 1 to 3 halogen atoms; R2 is alkyl, alkoxy, haloalkoxy, a halogen atom, cyano, etc.; and R3 is 7-oxo-7,8-dihydro-1,8-naphthyridinyl, 3-pyridyl, etc., or a salt thereof. The compound of the present invention has excellent antimicrobial activity against Clostridium difficile and is useful for the prevention or treatment of intestinal infection such as Clostridium difficile-associated diarrhea.
摘要翻译： 本发明提供由式（I）表示的化合物，其中X为氢原子或氟原子; R是氢原子或烷基; R1是（1）任选被1至3个卤素原子取代的环丙基或（2）任选被1至3个卤素原子取代的苯基; R2是烷基，烷氧基，卤代烷氧基，卤原子，氰基等; R3为7-氧代-7,8-二氢-1,8-二氮杂环丁烷基，3-吡啶基等，或其盐。 本发明的化合物对艰难梭菌具有优异的抗微生物活性，可用于预防或治疗肠道感染如难辨梭状芽孢杆菌相关性腹泻。
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