- 专利标题： ENANTIOSELECTIVE SYNTHESIS OF ALPHA-QUATERNARY MANNICH ADDUCTS BY PALLADIUM-CATALYZED ALLYLIC ALKYLATION
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申请号： US16579382申请日： 2019-09-23
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公开(公告)号： US20200157020A1公开(公告)日： 2020-05-21
- 发明人: Brian M. Stoltz , Yoshitaka Numajiri , Beau P. Pritchett , Koji Chiyoda
- 申请人： California Institute of Technology
- 主分类号： C07B53/00
- IPC分类号： C07B53/00 ; C07D209/88 ; C07D265/32 ; C07D211/76 ; C07D211/74 ; C07C271/18 ; C07C311/16 ; C07C271/50 ; C07C233/76
摘要：
This invention provides enantioenriched Mannich adducts with quaternary stereogenic centers and novel methods of preparing the compounds. Methods include the method for the preparation of a compound of formula (I): comprising treating a compound of formula (II): with a transition metal catalyst under alkylation conditions.
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