- 专利标题： Compositions and Methods Related to HIV-1 Immunogens
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申请号： US16780495申请日： 2020-02-03
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公开(公告)号： US20200165303A1公开(公告)日： 2020-05-28
- 发明人: Leopold Kong , Ian A. Wilson , Natalia De Val , Andrew B. Ward , Dennis Burton , Linling He , Jiang Zhu
- 申请人： The Scripps Research Institute
- 主分类号： C07K14/005
- IPC分类号： C07K14/005 ; A61K39/12 ; A61K47/64 ; A61K47/69
摘要：
The present invention provides HIV-1 vaccine immunogens. Some of the immunogens contain a soluble gp140-derived protein that harbors a modified N-terminus of the HR1 region in gp41. Some of the immunogens contain an HIV-1 Env-derived trimer protein that is presented on a nanoparticle platform. The invention also provides methods of using the HIV-1 vaccine immunogens for eliciting an immune response or treating HIV infections.
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