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公开(公告)号：US11236134B2
公开(公告)日：2022-02-01
申请号：US16780495
申请日：2020-02-03
发明人： Leopold Kong , Ian A. Wilson , Natalia De Val , Andrew B. Ward , Dennis Burton , Linling He , Jiang Zhu
摘要： The present invention provides HIV-1 vaccine immunogens. Some of the immunogens contain a soluble gp140-derived protein that harbors a modified N-terminus of the HR1 region in gp41. Some of the immunogens contain an HIV-1 Env-derived trimer protein that is presented on a nanoparticle platform. The invention also provides methods of using the HIV-1 vaccine immunogens for eliciting an immune response or treating HIV infections.
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公开(公告)号：US20190048043A1
公开(公告)日：2019-02-14
申请号：US16176200
申请日：2018-10-31
发明人： Leopold Kong , Ian A. Wilson , Natalia De Val , Andrew B. Ward , Dennis Burton , Linling He , Jiang Zhu
IPC分类号： C07K14/005
摘要： The present invention provides HIV-1 vaccine immunogens. Some of the immunogens contain a soluble gp140-derived protein that harbors a modified N-terminus of the HR1 region in gp41. Some of the immunogens contain an HIV-1 Env-derived trimer protein that is presented on a nanoparticle platform. The invention also provides methods of using the HIV-1 vaccine immunogens for eliciting an immune response or treating HIV infections.
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公开(公告)号：US11767347B2
公开(公告)日：2023-09-26
申请号：US17553070
申请日：2021-12-16
发明人： Leopold Kong , Ian A. Wilson , Natalia De Val , Andrew B. Ward , Dennis Burton , Linling He , Jiang Zhu
CPC分类号： C07K14/162 , A61K39/21 , A61K47/6929 , C07K14/005 , A61K39/12 , A61K47/64 , A61K2039/5258 , A61K2039/6031 , A61K2039/645 , C12N2740/16122 , C12N2740/16134
摘要： The present invention provides HIV-1 vaccine immunogens. Some of the immunogens contain a soluble gp140-derived protein that harbors a modified N-terminus of the HR1 region in gp41. Some of the immunogens contain an HIV-1 Env-derived trimer protein that is presented on a nanoparticle platform. The invention also provides methods of using the HIV-1 vaccine immunogens for eliciting an immune response or treating HIV infections.
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公开(公告)号：US20220098244A1
公开(公告)日：2022-03-31
申请号：US17553070
申请日：2021-12-16
发明人： Leopold Kong , Ian A. Wilson , Natalia De Val , Andrew B. Ward , Dennis Burton , Linling He , Jiang Zhu
IPC分类号： C07K14/16 , A61K47/69 , A61K39/21 , C07K14/005
摘要： The present invention provides HIV-1 vaccine immunogens. Some of the immunogens contain a soluble gp140-derived protein that harbors a modified N-terminus of the HR1 region in gp41. Some of the immunogens contain an HIV-1 Env-derived trimer protein that is presented on a nanoparticle platform. The invention also provides methods of using the HIV-1 vaccine immunogens for eliciting an immune response or treating HIV infections.
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公开(公告)号：US20200165303A1
公开(公告)日：2020-05-28
申请号：US16780495
申请日：2020-02-03
发明人： Leopold Kong , Ian A. Wilson , Natalia De Val , Andrew B. Ward , Dennis Burton , Linling He , Jiang Zhu
IPC分类号： C07K14/005 , A61K39/12 , A61K47/64 , A61K47/69
摘要： The present invention provides HIV-1 vaccine immunogens. Some of the immunogens contain a soluble gp140-derived protein that harbors a modified N-terminus of the HR1 region in gp41. Some of the immunogens contain an HIV-1 Env-derived trimer protein that is presented on a nanoparticle platform. The invention also provides methods of using the HIV-1 vaccine immunogens for eliciting an immune response or treating HIV infections.
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6.发明授权公开(公告)号：US10647748B2
公开(公告)日：2020-05-12
申请号：US16176200
申请日：2018-10-31
发明人： Leopold Kong , Ian A. Wilson , Natalia De Val , Andrew B. Ward , Dennis Burton , Linling He , Jiang Zhu
IPC分类号： C07K14/005 , A61K39/12 , A61K47/64 , A61K47/69 , A61K39/00
摘要： The present invention provides HIV-1 vaccine immunogens. Some of the immunogens contain a soluble gp140-derived protein that harbors a modified N-terminus of the HR1 region in gp41. Some of the immunogens contain an HIV-1 Env-derived trimer protein that is presented on a nanoparticle platform. The invention also provides methods of using the HIV-1 vaccine immunogens for eliciting an immune response or treating HIV infections.
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