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公开(公告)号：US20240083954A1
公开(公告)日：2024-03-14
申请号：US18449739
申请日：2023-08-15
发明人： Leopold Kong , Ian A. Wilson , Natalia de Val , Andrew B. Ward , Dennis Burton , Linling He , Jiang Zhu
IPC分类号： C07K14/16 , A61K39/21 , A61K47/69 , C07K14/005
CPC分类号： C07K14/162 , A61K39/21 , A61K47/6929 , C07K14/005 , A61K39/12 , C12N2740/16122 , C12N2740/16134
摘要： The present invention provides HIV-1 vaccine immunogens. Some of the immunogens contain a soluble gp140-derived protein that harbors a modified N-terminus of the HR1 region in gp41. Some of the immunogens contain an HIV-1 Env-derived trimer protein that is presented on a nanoparticle platform. The invention also provides methods of using the HIV-1 vaccine immunogens for eliciting an immune response or treating HIV infections.
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公开(公告)号：US20230190910A1
公开(公告)日：2023-06-22
申请号：US17896799
申请日：2022-08-26
发明人： Jiang Zhu , Linling He
IPC分类号： A61K39/12 , A61K47/64 , A61P31/18 , A61K39/21 , A61K9/51 , C07K14/16 , A61K38/16 , C07K14/005
CPC分类号： A61K39/12 , A61K47/646 , A61P31/18 , A61K39/21 , A61K9/51 , C07K14/162 , A61K38/162 , C07K14/005 , A61K47/69
摘要： The present invention provides novel scaffolded HIV-1 vaccine immunogens. Some of the scaffolded immunogens contain a soluble gp140 trimer linked to the N-terminus of the nanoparticle subunit and a T-helper epitope that is fused via a short peptide spacer to the C-terminus of the nanoparticle subunit. Some other immunogens of the invention contain a soluble gp140 trimer protein that is linked to a stable nanoparticle via a short peptide spacer that is a T-helper epitope. Some of the scaffolded immunogens contain a gp140 trimer immunogen presented on a nanoparticle platform formed with I3-01 protein, E2p, or variants of protein 1VLW. Also provided in the invention are nucleic acids that encode the various vaccine immunogens described herein, and expression vectors and host cells harboring the nucleic acids. The invention further provides methods of using the scaffolded HIV-1 vaccine immunogens for preventing or treating HIV infections.
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公开(公告)号：US20230181718A1
公开(公告)日：2023-06-15
申请号：US17743762
申请日：2022-05-13
发明人： Linling He , Jiang Zhu
IPC分类号： A61K39/21 , A61K39/145 , A61K39/215 , A61K39/29 , A61K39/12 , A61P31/18 , C12P21/00
CPC分类号： A61K39/21 , A61K39/145 , A61K39/215 , A61K39/29 , A61K39/12 , A61P31/18 , C12P21/00 , C12Y302/01096
摘要： The present invention provides methods for producing scaffolded (e.g., nanoparticle presented) or non-scaffolded vaccines that are based on viral immunogenic proteins with a glycan shielded (e.g., HIV-1 Env). The vaccines thus generated demonstrate enhanced immunogenicity and responder frequency. The methods entail (1) enzymatic digestion of glycan chain on the surface of a viral trimer protein immunogen or a self-assembling nanoparticle vaccine displaying the viral immunogen (e.g., an HIV-1 UFO trimer), or (2) expression of a construct encoding the vaccine in an expression system lacking normal glycosylation function for human proteins. Also provided in the invention are vaccine compositions produced with the described methods. The invention further provides methods of using the vaccine compositions described herein (e.g., scaffolded or non-scaffolded HIV-1 vaccines) in various therapeutic applications, e.g., for preventing or treating viral infections.
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公开(公告)号：US10780178B2
公开(公告)日：2020-09-22
申请号：US16177165
申请日：2018-10-31
发明人： Jiang Zhu , Linling He
IPC分类号： A61K39/21 , A61K47/64 , A61P31/18 , A61K9/51 , C07K14/16 , A61K47/69 , A61K38/16 , C07K14/005 , A61K39/12 , A61K39/00
摘要： The present invention provides novel scaffolded HIV-1 vaccine immunogens. Some of the scaffolded immunogens contain a soluble gp140 trimer linked to the N-terminus of the nanoparticle subunit and a T-helper epitope that is fused via a short peptide spacer to the C-terminus of the nanoparticle subunit. Some other immunogens of the invention contain a soluble gp140 trimer protein that is linked to a stable nanoparticle via a short peptide spacer that is a T-helper epitope. Some of the scaffolded immunogens contain a gp140 trimer immunogen presented on a nanoparticle platform formed with I3-01 protein, E2p, or variants of protein 1VLW. Also provided in the invention are nucleic acids that encode the various vaccine immunogens described herein, and expression vectors and host cells harboring the nucleic acids. The invention further provides methods of using the scaffolded HIV-1 vaccine immunogens for preventing or treating HIV infections.
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公开(公告)号：US20190125890A1
公开(公告)日：2019-05-02
申请号：US16177165
申请日：2018-10-31
发明人： Jiang Zhu , Linling He
摘要： The present invention provides novel scaffolded HIV-1 vaccine immunogens. Some of the scaffolded immunogens contain a soluble gp140 trimer linked to the N-terminus of the nanoparticle subunit and a T-helper epitope that is fused via a short peptide spacer to the C-terminus of the nanoparticle subunit. Some other immunogens of the invention contain a soluble gp140 trimer protein that is linked to a stable nanoparticle via a short peptide spacer that is a T-helper epitope. Some of the scaffolded immunogens contain a gp140 trimer immunogen presented on a nanoparticle platform formed with I3-01 protein, E2p, or variants of protein 1VLW. Also provided in the invention are nucleic acids that encode the various vaccine immunogens described herein, and expression vectors and host cells harboring the nucleic acids. The invention further provides methods of using the scaffolded HIV-1 vaccine immunogens for preventing or treating HIV infections.
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公开(公告)号：US20240140993A1
公开(公告)日：2024-05-02
申请号：US18503260
申请日：2023-11-07
发明人： Linling He , Jiang Zhu , Ian A. Wilson
IPC分类号： C07K14/005 , A61K39/215 , A61P31/14 , C12N7/00
CPC分类号： C07K14/005 , A61K39/215 , A61P31/14 , C12N7/00 , A61K2039/575
摘要： The present invention provides redesigned soluble coronavirus S protein derived immunogens that are stabilized via specific modifications in the wildtype soluble S sequences. Also provided in the invention are nanoparticle vaccines that contain the redesigned soluble S immunogens displayed on self-assembling nanoparticles. Polynucleotide sequences encoding the redesigned immunogens and the nanoparticle vaccines are also provided in the invention. The invention further provides methods of using the vaccine compositions in various therapeutic applications, e.g., for preventing or treating coronaviral infections.
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公开(公告)号：US11872277B2
公开(公告)日：2024-01-16
申请号：US17715658
申请日：2022-04-07
发明人： Linling He , Jiang Zhu , Anshul Chaudhary , Ian Wilson
CPC分类号： A61K39/12 , C07K14/473 , C12N7/00 , C07K2317/34 , C07K2319/735 , C12N2760/14134
摘要： The present invention provides novel engineered Ebolavirus GP proteins and polypeptides, scaffolded vaccine compositions that display the engineered proteins, and polynucleotides encoding the engineered proteins and scaffolded vaccine compositions. The invention also provides methods of using such engineered Ebolavirus GP proteins and vaccine compositions in various therapeutic applications, e.g., for preventing or treating Ebolavirus infections.
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公开(公告)号：US11767347B2
公开(公告)日：2023-09-26
申请号：US17553070
申请日：2021-12-16
发明人： Leopold Kong , Ian A. Wilson , Natalia De Val , Andrew B. Ward , Dennis Burton , Linling He , Jiang Zhu
CPC分类号： C07K14/162 , A61K39/21 , A61K47/6929 , C07K14/005 , A61K39/12 , A61K47/64 , A61K2039/5258 , A61K2039/6031 , A61K2039/645 , C12N2740/16122 , C12N2740/16134
摘要： The present invention provides HIV-1 vaccine immunogens. Some of the immunogens contain a soluble gp140-derived protein that harbors a modified N-terminus of the HR1 region in gp41. Some of the immunogens contain an HIV-1 Env-derived trimer protein that is presented on a nanoparticle platform. The invention also provides methods of using the HIV-1 vaccine immunogens for eliciting an immune response or treating HIV infections.
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9.发明公开公开(公告)号：US20230181717A1
公开(公告)日：2023-06-15
申请号：US17550768
申请日：2021-12-14
发明人： Linling He , Jiang Zhu
CPC分类号： A61K39/21 , A61K47/6929 , A61P31/18 , A61K9/51 , A61K38/162 , C07K14/162 , A61K2039/55516
摘要： The present invention provides methods for producing HIV-1 nanoparticle vaccines with enhanced immunogenicity. The methods entail (1) enzymatic digestion of glycan chain on the surface of a self-assembling nanoparticle vaccine displaying an HIV-1 Env derived trimer immunogen, or (2) expression of an HIV-1 nanoparticle construct in an expression system lacking normal glycosylation function for human proteins. Also provided in the invention are HIV-1 nanoparticle vaccines produced with the described methods. The invention further provides methods of using the HIV-1 nanoparticle vaccine compositions described herein in various therapeutic applications, e.g., for preventing or treating viral infections.
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公开(公告)号：US11305004B2
公开(公告)日：2022-04-19
申请号：US17397340
申请日：2021-08-09
发明人： Linling He , Jiang Zhu , Anshul Chaudhary , Ian Wilson
摘要： The present invention provides novel engineered Ebolavirus GP proteins and polypeptides, as well as scaffolded vaccine compositions that display the engineered proteins. The invention also provides methods of using such engineered Ebolavirus GP proteins and vaccine compositions in various therapeutic applications, e.g., for preventing or treating Ebolavirus infections.
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