Enhanced cleaning of a fouled membrane is achieved via controlled deformation in a method wherein a feed composition, comprising a solvent and dissolved components, flows into a retentate side of a membrane module. The solvent passes through the membrane from the retentate side to a permeate or draw side of the membrane module while retaining the dissolved components on the membrane. As a foulant accumulates on either side of the membrane, a driving force is generated across the membrane, wherein the membrane responds cyclically by deforming back and forth toward the permeate or draw side and toward the retentate side. The foulant is dislodged from the membrane via mechanical fatigue at the foulant-membrane interface caused by the deformation of the membrane and contact with a spacer in contact with the membrane.