- 专利标题： MACROCYCLIC MCL-1 INHIBITORS AND METHODS OF USE
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申请号： US17079141申请日： 2020-10-23
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公开(公告)号： US20210292339A1公开(公告)日： 2021-09-23
- 发明人: Wilfried BRAJE , George DOHERTY , Katja JANTOS , Cheng JI , Andrew JUDD , Aaron KUNZER , Anthony MASTRACCHIO , Xiaohong SONG , Andrew SOUERS , Gerard SULLIVAN , Zhi-Fu TAO , Chunqiu LAI , Jesse TESKE , Michael WENDT , Patrick BRADY , Xilu WANG , Thomas PENNING , Yujia DAI , Jane GONG , Roberto RISI , Yiyun YU , Guidong ZHU
- 申请人： AbbVie Inc. , AbbVie Deutschland GmbH & Co. KG
- 申请人地址： US IL North Chicago; DE Wiesbaden
- 专利权人： AbbVie Inc.,AbbVie Deutschland GmbH & Co. KG
- 当前专利权人： AbbVie Inc.,AbbVie Deutschland GmbH & Co. KG
- 当前专利权人地址： US IL North Chicago; DE Wiesbaden
- 主分类号： C07D498/18
- IPC分类号： C07D498/18 ; A61P35/00 ; C07D519/00 ; C07D495/18 ; C07D495/16 ; A61K31/519 ; C07D491/16 ; C07D498/16
摘要：
The present disclosure provides for compounds of Formula (I) wherein A2, A3, A4, A6, A7, A8, A15, RA, R5, R9, R10A, R10B, R11, R12, R13, R14, R16, W, X, and Y have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents for the treatment of diseases and conditions, including cancer. Also provided are pharmaceutical compositions comprising compounds of Formula (I).
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