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公开(公告)号：US20200239494A1
公开(公告)日：2020-07-30
申请号：US16639555
申请日：2018-08-15
发明人： Wilfried BRAJE , George DOHERTY , Katja JANTOS , Cheng JI , Andrew JUDD , Aaron KUNZER , Anthony MASTRACCHIO , Xiaohong SONG , Andrew SOUERS , Gerard SULLIVAN , Zhi-Fu TAO , Chunqiu LAI , Andreas KLING , Frauke POHLKI , Jesse TESKE , Michael WENDT , Patrick BRADY , Xilu WANG , Thomas PENNING , Michael Michaelides
IPC分类号： C07D495/16 , C07D519/00 , A61P35/00
摘要： The present disclosure provides for compounds of Formula (I) wherein A2, A3, A4, A6, A7, A8, A15, RA, R5, R9, R10A, R10B, R11, R12, R13, R14, R16, W, X, and Y have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including cancer. Also provided are pharmaceutical compositions comprising compounds of Formula (I).
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公开(公告)号：US20200255451A1
公开(公告)日：2020-08-13
申请号：US16639560
申请日：2018-08-15
发明人： Wilfried BRAJE , George DOHERTY , Katja JANTOS , Cheng JI , Andrew JUDD , Aaron KUNZER , Anthony MASTRACCHIO , Xiaohong SONG , Andrew SOUERS , Gerard SULLIVAN , Zhi-Fu TAO , Chunqiu LAI , Andreas KLING , Frauke POHLKI , Jesse TESKE , Michael WENDT , Patrick BRADY , Xilu WANG , Thomas PENNING , Yujia DAI , Jane GONG , Roberto RISI , Yiyun YU , Guidong ZHU , Dominique POTIN , Fabrice Guillier
IPC分类号： C07D498/16 , C07D491/16 , C07D495/16 , C07D519/00 , A61P35/00
摘要： The present disclosure provides for compounds of Formula (I) wherein A2, A3, A4, A6, A7, A8, A15, RA, R5, R9, R10A, R10B, R11, R12, R13, R14, R16, W, X, and Y have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents for the treatment of diseases and conditions, including cancer. Also provided are pharmaceutical compositions comprising compounds of Formula (I).
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公开(公告)号：US20210292339A1
公开(公告)日：2021-09-23
申请号：US17079141
申请日：2020-10-23
发明人： Wilfried BRAJE , George DOHERTY , Katja JANTOS , Cheng JI , Andrew JUDD , Aaron KUNZER , Anthony MASTRACCHIO , Xiaohong SONG , Andrew SOUERS , Gerard SULLIVAN , Zhi-Fu TAO , Chunqiu LAI , Jesse TESKE , Michael WENDT , Patrick BRADY , Xilu WANG , Thomas PENNING , Yujia DAI , Jane GONG , Roberto RISI , Yiyun YU , Guidong ZHU
IPC分类号： C07D498/18 , A61P35/00 , C07D519/00 , C07D495/18 , C07D495/16 , A61K31/519 , C07D491/16 , C07D498/16
摘要： The present disclosure provides for compounds of Formula (I) wherein A2, A3, A4, A6, A7, A8, A15, RA, R5, R9, R10A, R10B, R11, R12, R13, R14, R16, W, X, and Y have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents for the treatment of diseases and conditions, including cancer. Also provided are pharmaceutical compositions comprising compounds of Formula (I).
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