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公开(公告)号：US20210292339A1
公开(公告)日：2021-09-23
申请号：US17079141
申请日：2020-10-23
发明人： Wilfried BRAJE , George DOHERTY , Katja JANTOS , Cheng JI , Andrew JUDD , Aaron KUNZER , Anthony MASTRACCHIO , Xiaohong SONG , Andrew SOUERS , Gerard SULLIVAN , Zhi-Fu TAO , Chunqiu LAI , Jesse TESKE , Michael WENDT , Patrick BRADY , Xilu WANG , Thomas PENNING , Yujia DAI , Jane GONG , Roberto RISI , Yiyun YU , Guidong ZHU
IPC分类号： C07D498/18 , A61P35/00 , C07D519/00 , C07D495/18 , C07D495/16 , A61K31/519 , C07D491/16 , C07D498/16
摘要： The present disclosure provides for compounds of Formula (I) wherein A2, A3, A4, A6, A7, A8, A15, RA, R5, R9, R10A, R10B, R11, R12, R13, R14, R16, W, X, and Y have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents for the treatment of diseases and conditions, including cancer. Also provided are pharmaceutical compositions comprising compounds of Formula (I).
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公开(公告)号：US20200239494A1
公开(公告)日：2020-07-30
申请号：US16639555
申请日：2018-08-15
发明人： Wilfried BRAJE , George DOHERTY , Katja JANTOS , Cheng JI , Andrew JUDD , Aaron KUNZER , Anthony MASTRACCHIO , Xiaohong SONG , Andrew SOUERS , Gerard SULLIVAN , Zhi-Fu TAO , Chunqiu LAI , Andreas KLING , Frauke POHLKI , Jesse TESKE , Michael WENDT , Patrick BRADY , Xilu WANG , Thomas PENNING , Michael Michaelides
IPC分类号： C07D495/16 , C07D519/00 , A61P35/00
摘要： The present disclosure provides for compounds of Formula (I) wherein A2, A3, A4, A6, A7, A8, A15, RA, R5, R9, R10A, R10B, R11, R12, R13, R14, R16, W, X, and Y have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including cancer. Also provided are pharmaceutical compositions comprising compounds of Formula (I).
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公开(公告)号：US20200255451A1
公开(公告)日：2020-08-13
申请号：US16639560
申请日：2018-08-15
发明人： Wilfried BRAJE , George DOHERTY , Katja JANTOS , Cheng JI , Andrew JUDD , Aaron KUNZER , Anthony MASTRACCHIO , Xiaohong SONG , Andrew SOUERS , Gerard SULLIVAN , Zhi-Fu TAO , Chunqiu LAI , Andreas KLING , Frauke POHLKI , Jesse TESKE , Michael WENDT , Patrick BRADY , Xilu WANG , Thomas PENNING , Yujia DAI , Jane GONG , Roberto RISI , Yiyun YU , Guidong ZHU , Dominique POTIN , Fabrice Guillier
IPC分类号： C07D498/16 , C07D491/16 , C07D495/16 , C07D519/00 , A61P35/00
摘要： The present disclosure provides for compounds of Formula (I) wherein A2, A3, A4, A6, A7, A8, A15, RA, R5, R9, R10A, R10B, R11, R12, R13, R14, R16, W, X, and Y have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents for the treatment of diseases and conditions, including cancer. Also provided are pharmaceutical compositions comprising compounds of Formula (I).
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4.发明申请APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES 有权用于治疗癌症和免疫和自发性疾病的病毒诱导剂公开(公告)号：US20150183775A1
公开(公告)日：2015-07-02
申请号：US14582144
申请日：2014-12-23
申请人： AbbVie Inc.
发明人： Milan BRUNCKO , Yujia DAI , Hong DING , George A. DOHERTY , Steven W. ELMORE , Lisa HASVOLD , Laura HEXAMER , Aaron R. KUNZER , Robert A. MANTEI , Chang H. PARK , Cheol-Min PARK , Andrew M. PETROS , Xiaohong SONG , Andrew J. SOUERS , Gerard M. SULLIVAN , Zhi-Fu TAO , Gary T. WANG , Le WANG , Xilu WANG , Michael D. WENDT , William J. MCCLELLAN
IPC分类号： C07D417/12 , C07D405/12 , C07D413/12 , C07D401/12
CPC分类号： C07D209/08 , A61K31/635 , C07D211/58 , C07D213/74 , C07D213/84 , C07D231/56 , C07D235/06 , C07D277/24 , C07D295/30 , C07D309/04 , C07D309/08 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/12 , C07D417/12 , C07D471/04
摘要： Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
摘要翻译： 公开了抑制抗凋亡Bcl-2蛋白活性的化合物，含有化合物的组合物和治疗疾病的方法，其中表达抗凋亡Bcl-2蛋白。
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公开(公告)号：US20210346369A1
公开(公告)日：2021-11-11
申请号：US17108719
申请日：2020-12-01
申请人： AbbVie Inc.
发明人： Le WANG , George DOHERTY , Xilu WANG , Zhi-Fu TAO , Milan BRUNCKO , Aaron R. KUNZER , Michael D. WENDT , Xiaohong SONG , Robin FREY , Todd M. HANSEN , Gerard M. SULLIVAN , Andrew JUDD , Andrew SOUERS
IPC分类号： A61K31/4725 , C07D471/04 , A61K31/5377 , A61K45/06 , C07D417/14
摘要： Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-xL protein.
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6.发明申请公开(公告)号：US20200345717A1
公开(公告)日：2020-11-05
申请号：US16719794
申请日：2019-12-18
申请人： AbbVie Inc.
发明人： Le WANG , George DOHERTY , Xilu WANG , Zhi-Fu TAO , Milan BRUNCKO , Aaron R. KUNZER , Michael D. WENDT , Xiaohong SONG , Robin FREY , Todd M. HANSEN , Gerard M. SULLIVAN , Andrew JUDD , Andrew SOUERS
IPC分类号： A61K31/4725 , C07D471/04 , A61K31/5377 , A61K45/06 , C07D417/14
摘要： Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-xL protein.
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7.发明公开公开(公告)号：US20240285611A1
公开(公告)日：2024-08-29
申请号：US18450394
申请日：2023-08-15
申请人： ABBVIE INC.
发明人： Le WANG , George DOHERTY , Xilu WANG , Zhi-Fu TAO , Milan BRUNCKO , Aaron R. KUNZER , Michael D. WENDT , Xiaohong SONG , Robin FREY , Todd M. HANSEN , Gerard M. SULLIVAN , Andrew JUDD , Andrew SOUERS
IPC分类号： A61K31/4725 , A61K31/4985 , A61K31/5025 , A61K31/5377 , A61K31/541 , C07D401/04 , C07D417/14 , C07D471/04 , C07D487/04 , C07D493/08 , C07D513/04
CPC分类号： A61K31/4725 , A61K31/4985 , A61K31/5025 , A61K31/5377 , A61K31/541 , C07D401/04 , C07D417/14 , C07D471/04 , C07D487/04 , C07D493/08 , C07D513/04
摘要： Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-xL protein.
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公开(公告)号：US20220315555A1
公开(公告)日：2022-10-06
申请号：US17518249
申请日：2021-11-03
发明人： Milan BRUNCKO , Hong DING , George A. DOHERTY , Steven W. ELMORE , Lisa A. HASVOLD , Laura HEXAMER , Aaron R. KUNZER , Xiaohong SONG , Andrew J. SOUERS , Gerard M. SULLIVAN , Zhi-Fu TAO , Gary T. WANG , Le WANG , Xilu WANG , Michael D. WENDT , Robert MANTEI , Todd M. HANSEN
IPC分类号： C07D401/12 , C07D401/14 , C07D519/00 , C07D471/04 , C07D209/82 , C07D403/12 , A61K31/496
摘要： Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
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9.发明申请公开(公告)号：US20180221363A1
公开(公告)日：2018-08-09
申请号：US15845835
申请日：2017-12-18
申请人： AbbVie Inc.
发明人： Le WANG , George DOHERTY , Xilu WANG , Zhi-Fu TAO , Milan BRUNCKO , Aaron R. KUNZER , Michael D. WENDT , Xiaohong SONG , Robin FREY , Todd M. HANSEN , Gerard M. SULLIVAN , Andrew JUDD , Andrew SOUERS
IPC分类号： A61K31/4725 , C07D417/14 , C07D471/04 , A61K31/5377 , A61K45/06
CPC分类号： A61K31/4725 , A61K31/5377 , A61K45/06 , C07D417/14 , C07D471/04
摘要： Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-xL protein.
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