- 专利标题： MODIFIED LIGAND-GATED ION CHANNELS AND METHODS OF USE
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申请号： US17468907申请日： 2021-09-08
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公开(公告)号： US20210403522A1公开(公告)日： 2021-12-30
- 发明人: Scott Sternson , Peter Lee , Christopher Magnus
- 申请人： Howard Hughes Medical Institute
- 申请人地址： US MD Chevy Chase
- 专利权人： Howard Hughes Medical Institute
- 当前专利权人： Howard Hughes Medical Institute
- 当前专利权人地址： US MD Chevy Chase
- 主分类号： C07K14/47
- IPC分类号： C07K14/47 ; A61K38/01 ; A61K38/17 ; C07K14/705 ; C12N15/00 ; C12N15/09
摘要：
This document relates to materials and methods for controlling ligand gated ion channel (LGIC) activity. For example, modified LGICs including at least one LGIC subunit having a modified ligand binding domain (LBD) and/or a modified ion pore domain (IPD) are provided. Also provided are exogenous LGIC ligands that can bind to and activate the modified LGIC, as well as methods of modulating ion transport across the membrane of a cell of a mammal, methods of modulating the excitability of a cell in a mammal, and methods of treating a mammal having a channelopathy.
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