- 专利标题： PIPERAZINYL AND PIPERIDINYL QUINAZOLIN-4(3H)-ONE DERIVATIVES HAVING ACTIVITY AGAINST PAIN
-
申请号： US17290747申请日： 2019-10-31
-
公开(公告)号： US20220002314A1公开(公告)日： 2022-01-06
- 发明人: Ariadna FERNÁNDEZ-DONIS , Jose Luís DÍAZ-FERNÁNDEZ , Carmen ALMANSA-ROSALES , Adriana LORENTE-CRIVILLÉ
- 申请人： ACONDICIONAMIENTO TARRASENSE
- 申请人地址： ES Terrassa (Barcelona)
- 专利权人： ACONDICIONAMIENTO TARRASENSE
- 当前专利权人： ACONDICIONAMIENTO TARRASENSE
- 当前专利权人地址： ES Terrassa (Barcelona)
- 优先权： EP18382772.4 20181031
- 国际申请： PCT/EP2019/079846 WO 20191031
- 主分类号： C07D498/10
- IPC分类号： C07D498/10 ; C07D471/04 ; C07D403/06 ; C07D239/90 ; C07D405/14 ; C07D401/14 ; C07D403/14 ; C07D471/18
摘要：
The present invention relates to piperazinyl and piperidinyl quinazolin-4(3H)-one derivatives having pharmacological activity towards the α2δ subunit, in particular the α2δ-1 subunit, of the voltage-gated calcium channel, in particular having dual pharmacological activity towards both the α2δ subunit, in particular the α2δ-1 subunit, of the voltage-gated calcium channel and the μ-opioid receptor. The present invention also relates to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.
信息查询
