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    Alkylaminoproline Derivatives as alpha-2-delta-1 Blockers
    7.
    发明申请
    Alkylaminoproline Derivatives as alpha-2-delta-1 Blockers 有权

    公开(公告)号：US20230100599A1

    公开(公告)日：2023-03-30

    申请号：US17975652

    申请日：2022-10-28

    申请人： ACONDICIONAMIENTO TARRASENSE

    发明人： Anita WEGERT ,  Carmen ALMANSA-ROSALES

    IPC分类号： C07D207/16

    摘要： The present invention relates to compounds showing pharmacological activity towards the subunit α2δ # of voltage-gated calcium channels (VGCC), especially the α2δ-1 subunit of voltage-gated calcium channels. More particularly, the invention relates to alkylaminoproline derivatives having this pharmacological activity, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain and/or as neuroprotective agents.

    THERMO-RESPONSIVE DUAL BAND ELECTROCHROMIC DEVICE
    9.
    发明申请
    THERMO-RESPONSIVE DUAL BAND ELECTROCHROMIC DEVICE 有权

    公开(公告)号：US20220350218A1

    公开(公告)日：2022-11-03

    申请号：US17765696

    申请日：2020-09-25

    申请人： ACONDICIONAMIENTO TARRASENSE

    发明人： Michele Andrea MANCA

    IPC分类号： G02F1/1516 ,  G02F1/155 ,  G02F1/1503 ,  G02F1/1343

    摘要： It relates to a thermo-responsive dual band electrochromic device, which is capable of selectively controlling the amount of sunlight radiation transmitted in the visible and in the near-infrared regions by operating under four distinct optical regimes, namely: fully transparent, visible blocking, near-infrared blocking, and fully blocking. The device can be regulated either by an electric stimulus, namely by controlling the sign and the intensity of the applied bias voltage, or by a thermal stimulus. In the latter the attenuation of incoming thermal radiation results increased as temperature increases. The thermo-responsive dual band electrochromic device comprises a first electrode consisting of a first transparent conductive substrate topped by a first electro-optically active layer and a second electrode consisting of a second transparent conductive substrate topped by a second electro-optically active layer separated by a temperature-dependent ion conductive layer consisting of a thermo-responsive polymer gel, an ion conductor and a plasticizer.

    Alkylaminoproline derivatives as alpha-2-delta-1 blockers
    10.
    发明授权
    Alkylaminoproline derivatives as alpha-2-delta-1 blockers 有权

    公开(公告)号：US11905243B2

    公开(公告)日：2024-02-20

    申请号：US17975652

    申请日：2022-10-28

    申请人： ACONDICIONAMIENTO TARRASENSE

    发明人： Anita Wegert ,  Carmen Almansa-Rosales

    IPC分类号： C07D207/16

    CPC分类号： C07D207/16

    摘要： The present invention relates to compounds showing pharmacological activity towards the subunit α2δ#of voltage-gated calcium channels (VGCC), especially the α2δ-1 subunit of voltage-gated calcium channels. More particularly, the invention relates to alkylaminoproline derivatives having this pharmacological activity, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain and/or as neuroprotective agents.