专利检索 ap:("ACONDICIONAMIENTO TARRASENSE") AND inv:"Adriana LORENTE-CRIVILLÉ" 第 1 页

1.

发明公开
NEW PYRAZOLO[1,5-a] PYRIMIDINE DERIVATIVES AS SIGMA LIGANDS 审中-公开

公开(公告)号：US20240246966A1

公开(公告)日：2024-07-25

申请号：US18555720

申请日：2022-04-08

申请人： ACONDICIONAMIENTO TARRASENSE

发明人： Adriana LORENTE-CRIVILLÉ , Carmen ALMANSA-ROSALES

IPC分类号： C07D471/04 , A61K31/444 , A61K31/4545 , A61K31/519 , A61K31/553 , C07D487/04 , C07D519/00

CPC分类号： C07D471/04 , A61K31/444 , A61K31/4545 , A61K31/519 , A61K31/553 , C07D487/04 , C07D519/00

摘要： The present invention relates to new compounds of formula (I″):

as sigma ligands having a great affinity for sigma receptors, sigma-1 receptor (σ1) and/or sigma-2 receptor (σ2). The present invention also refers to the process for the preparation thereof, to compositions comprising them, and to their use as medicaments.

2.

发明申请
PIPERAZINYL AND PIPERIDINYL QUINAZOLIN-4(3H)-ONE DERIVATIVES HAVING ACTIVITY AGAINST PAIN 有权

公开(公告)号：US20220002314A1

公开(公告)日：2022-01-06

申请号：US17290747

申请日：2019-10-31

申请人： ACONDICIONAMIENTO TARRASENSE

发明人： Ariadna FERNÁNDEZ-DONIS , Jose Luís DÍAZ-FERNÁNDEZ , Carmen ALMANSA-ROSALES , Adriana LORENTE-CRIVILLÉ

IPC分类号： C07D498/10 , C07D471/04 , C07D403/06 , C07D239/90 , C07D405/14 , C07D401/14 , C07D403/14 , C07D471/18

摘要： The present invention relates to piperazinyl and piperidinyl quinazolin-4(3H)-one derivatives having pharmacological activity towards the α2δ subunit, in particular the α2δ-1 subunit, of the voltage-gated calcium channel, in particular having dual pharmacological activity towards both the α2δ subunit, in particular the α2δ-1 subunit, of the voltage-gated calcium channel and the μ-opioid receptor. The present invention also relates to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.

3.

发明公开
New 2,3-Dihydro-1H-pyrrolo[3,2-b]pyridine Derivatives as Sigma Ligands 审中-公开

公开(公告)号：US20240174671A1

公开(公告)日：2024-05-30

申请号：US18549907

申请日：2022-03-08

申请人： ACONDICIONAMIENTO TARRASENSE

发明人： Marina VIRGILI-BERNADÓ , Mónica ALONSO-XALMA , Carmen ALMANSA-ROSALES , Jose Luís DÍAZ-FERNÁNDEZ , Adriana LORENTE-CRIVILLÉ

IPC分类号： C07D471/04 , A61K31/437 , C07D519/00

CPC分类号： C07D471/04 , A61K31/437 , C07D519/00

摘要： The present invention relates to new 2,3-dihydro-1H-pyrrolo[3,2-b]pyridine derivatives of formula (I):

as sigma ligands having a great affinity for sigma receptors, especially sigma-1 (σ1) and/or sigma-2 (σ2) receptors, as well as to the process for the preparation thereof, to compositions comprising them, and to their use as medicaments.