Disclosed embodiments relate to systems and methods to performing instructions structured to compute a plurality of cryptic rounds of the block cipher. In one example, a processor includes fetch and decode circuitry to fetch and decode a single instruction comprising a first field to identify a destination of a first operand, a second field to identify a source of a second operand comprising an input state, a third field to identify a source of a third operand comprising a round key. The processor includes execution circuitry to execute the decoded instruction to compute a plurality of cryptic rounds of the block cipher by performing a round function on data elements of the second operand and the third operand to generate a word.