A method of performing a process using a plurality of control signals and resulting in a plurality of measurable outcomes is described. The method includes optimizing the plurality of control signals by at least: receiving a plurality of process constraints; receiving, for each measurable outcome, an optimum range; receiving, for each control signal, a plurality of potential optimum values; iteratively performing the process, where for each process iteration, the value of each control signal is selected from among the plurality of potential optimum values received for the control signal; for each process iteration, measuring each outcome in the plurality of measurable outcomes; and generating confidence intervals for the control signals to determine a causal relationship between the control signals and the measurable outcomes. The method includes performing the process using at least the control signals determined by the causal relationship to causally affect at least one of the measurable outcomes.