Invention Application
- Patent Title: ANTIBODIES SPECIFIC FOR HYPERPHOSPHORYLATED TAU AND METHODS OF USE THEREOF
-
Application No.: US17399205Application Date: 2021-08-11
-
Publication No.: US20220177557A1Publication Date: 2022-06-09
- Inventor: Jan Torleif Pedersen , Kristian Kjaergaard , Lars Østergaard Pedersen , Ayodeji Abdur-Rasheed Asuni , Nina Helen Rosenqvist , Justus Claus Alfred Daechsel , Karsten Juhl , Lena Tagmose , Mauro Marigo , Thomas Jensen , Søren Christensen , Laurent David , Christiane Volbracht , Lone Helboe
- Applicant: H. Lundbeck A/S
- Applicant Address: DK Valby
- Assignee: H. Lundbeck A/S
- Current Assignee: H. Lundbeck A/S
- Current Assignee Address: DK Valby
- Priority: DKPA201600416 20160712,DKPA201700005 20170104,DKPA201700008 20170104,DKPA201700179 20170314
- Main IPC: C07K16/18
- IPC: C07K16/18 ; A61K39/395 ; A61K49/00 ; G01N33/68
Abstract:
The present invention relates to a class of monoclonal antibody that specifically binds the phosphorylated serine 396 residue on pathological hyperphosphorylated (PH F) tau (pS396) with improved affinity, as well as to methods of using these molecules and their tau binding fragments in the treatment of Alzheimer's disease and other tauopathies.
Public/Granted literature
- US12129289B2 Antibodies specific for hyperphosphorylated tau and methods of use thereof Public/Granted day:2024-10-29
Information query
