- 专利标题： SIALIDASE-RESISTANT SACCHARIDE AND METHOD OF MAKING AND USING THE SAME
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申请号： US17598064申请日： 2020-03-10
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公开(公告)号： US20220267363A1公开(公告)日： 2022-08-25
- 发明人: Chi-Huey Wong , Hong-Jay Lo
- 申请人： Academia Sinica
- 申请人地址： TW Taipei
- 专利权人： Academia Sinica
- 当前专利权人： Academia Sinica
- 当前专利权人地址： TW Taipei
- 国际申请： PCT/US2020/014608 WO 20200310
- 主分类号： C07H15/18
- IPC分类号： C07H15/18 ; C07H1/00 ; C07K16/28
摘要：
Disclosed are a method of preparing a saccharide that contains a 3-fluoro-sialic acid and a method of bonding it to a homogeneous antibody. Also within the scope of this invention are compounds each containing a 3-fluoro-sialic acid, monoclonal antibodies bonded to α2,6-linked 3-fluoro-sialo-side terminated N-glycans, and treatment of cancer with such monoclonal antibodies.
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