- 专利标题: EXPANDABLE LIVER ORGANOIDS, MEDIA COMPOSITION FOR DIFFERENTIATION THEREOF, AND METHOD FOR PRODUCING LIVER ORGANOIDS USING THE SAME
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申请号: US17686669申请日: 2022-03-04
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公开(公告)号: US20220308045A1公开(公告)日: 2022-09-29
- 发明人: Myung Jin SON , Kyung-Sook CHUNG , Seonju MUN , Jae Sung RYU , Cho-Rok JUNG , Hyun-Soo CHO , Dae Soo KIM
- 申请人: KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY
- 申请人地址: KR Daejeon
- 专利权人: KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY
- 当前专利权人: KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY
- 当前专利权人地址: KR Daejeon
- 优先权: KR10-2019-0109378 20190904
- 主分类号: G01N33/50
- IPC分类号: G01N33/50 ; G01N33/68 ; C12Q1/6851 ; C12N5/071
摘要:
The present invention relates to expandable liver organoids, a medium composition for differentiation thereof, and a method for producing liver organoids using the same, and the liver organoids according to the present invention exhibit the characteristics of more mature hepatocytes than 2D differentiated hepatocytes, can be subcultured up to 90 times or more, and exhibit the expandability for maintaining the characteristics of mature hepatocytes even after multiple subcultures, and thus can be usefully utilized for predicting toxicity, regeneration, and inflammatory response, drug screening, and modeling of diseases such as hepatic steatosis.