A method for controlling a vehicle can include determining a driver state based on physiological response of an operator and navigational irregularities from observed driving patterns. The physiological response may indicate observed driver stress based on bodily responses that can include respiration, heart rate, ocular movement, or other stress indicators. The method further includes determining a vehicle route having a trip start position, a path to a present position, and a trip destination, and identifying a navigation irregularity based on the vehicle route, the driver state, and a historic record driving patterns. The method may include displaying a navigation assistant output on a heads-up Human Machine Interface (HMI) based on the navigation irregularity and the physiological response of the user. The system may provide user-selectable navigation assistance including placing a phone call to a family member for navigation guidance, providing turn-by-turn navigation guidance via the heads-up HMI, and/or other measures.