- 专利标题: Gold-Platinum Based Bi-Metallic Nanocrystal Suspensions, Electrochemical Manufacturing Processes Therefor and Uses for the Same
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申请号: US17708253申请日: 2022-03-30
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公开(公告)号: US20230172975A1公开(公告)日: 2023-06-08
- 发明人: Adam R. Dorfman , David A. Bryce , Maxwell A. Grace , D. Kyle Pierce , Mikhail Merzliakov , Mark G. Mortenson
- 申请人: Adam R. Dorfman , David A. Bryce , Maxwell A. Grace , D. Kyle Pierce , Mikhail Merzliakov , Mark G. Mortenson
- 申请人地址: US MD Baltimore
- 专利权人: GR Intellectual Reserve, LLC
- 当前专利权人: GR Intellectual Reserve, LLC
- 当前专利权人地址: US MD Havre de Grace
- 分案原申请号: US15204534 2016.07.07
- 主分类号: A61K33/243
- IPC分类号: A61K33/243 ; A61K9/14 ; A61K9/10 ; A61K33/242 ; C22C1/04 ; C22C5/02 ; C22C5/04 ; C22C30/00 ; A61K9/16
摘要:
The present invention relates to novel gold-platinum based bi-metallic nanocrystal suspensions that have nanocrystal surfaces that are substantially free from organic or other impurities or films associated with typical chemical reductants/stabilizers and/or raw materials used in nanoparticle formation processes. Specifically, the surfaces are “clean” relative to the surfaces of metal-based nanoparticles made using chemical reduction (and other) processes that require organic (or other) reductants and/or surfactants to grow (and/or suspend) metal nanoparticles from metal ions in a solution.
The invention includes novel electrochemical manufacturing apparatuses and techniques for making the bi-metallic nanocrystal suspensions. The techniques do not require the use or presence of chlorine ions/atoms and/or chlorides or chlorine-based materials for the manufacturing process/final suspension. The invention further includes pharmaceutical compositions thereof and the use of the bi-metallic nanocrystals or suspensions or colloids thereof for the treatment or prevention of diseases or conditions for which metal-based therapy is already known, including, for example, for cancerous diseases or conditions.
The invention includes novel electrochemical manufacturing apparatuses and techniques for making the bi-metallic nanocrystal suspensions. The techniques do not require the use or presence of chlorine ions/atoms and/or chlorides or chlorine-based materials for the manufacturing process/final suspension. The invention further includes pharmaceutical compositions thereof and the use of the bi-metallic nanocrystals or suspensions or colloids thereof for the treatment or prevention of diseases or conditions for which metal-based therapy is already known, including, for example, for cancerous diseases or conditions.
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