公开(公告)号：US09387225B2

公开(公告)日：2016-07-12

申请号：US14008931

申请日：2012-03-30

申请人： Adam R. Dorfman ,  David A. Bryce ,  Maxwell A. Grace ,  D. Kyle Pierce ,  Mikhail Merzliakov ,  Mark G. Mortenson

发明人： Adam R. Dorfman ,  David A. Bryce ,  Maxwell A. Grace ,  D. Kyle Pierce ,  Mikhail Merzliakov ,  Mark G. Mortenson

IPC分类号： A61K33/24 ,  A61K9/14 ,  C22C1/04 ,  C22C5/02 ,  C22C5/04 ,  C22C30/00 ,  A61K9/10

CPC分类号： A61K33/24 ,  A61K9/10 ,  A61K9/14 ,  A61K9/1611 ,  B82Y5/00 ,  C22C1/0466 ,  C22C5/02 ,  C22C5/04 ,  C22C30/00

摘要： The present invention relates to novel gold-platinum based bi-metallic nanocrystal suspensions that have nanocrystal surfaces that are substantially free from organic or other impurities or films associated with typical chemical reductants/stabilizers and/or raw materials used in nanoparticle formation processes. Specifically, the surfaces are “clean” relative to the surfaces of metal-based nanoparticles made using chemical reduction (and other) processes that require organic (or other) reductants and/or surfactants to grow (and/or suspend) metal nanoparticles from metal ions in a solution. The invention includes novel electrochemical manufacturing apparatuses and techniques for making the bi-metallic nanocrystal suspensions. The techniques do not require the use or presence of chlorine ions/atoms and/or chlorides or chlorine-based materials for the manufacturing process/final suspension. The invention further includes pharmaceutical compositions thereof and the use of the bi-metallic nanocrystals or suspensions or colloids thereof for the treatment or prevention of diseases or conditions for which metal-based therapy is already known, including, for example, for cancerous diseases or conditions.

摘要翻译： 本发明涉及具有纳米晶体表面的新型金 - 铂基双金属纳米晶体悬浮液，其基本上不含与用于纳米颗粒形成过程中的典型化学还原剂/稳定剂和/或原料相关的有机或其它杂质或膜。 具体地说，相对于使用需要有机（或其它）还原剂和/或表面活性剂从金属生长（和/或悬浮）金属纳米粒子的化学还原（和其它）方法制备的金属基纳米颗粒的表面，表面“干净” 离子在溶液中。 本发明包括用于制备双金属纳米晶体悬浮液的新型电化学制造装置和技术。 这些技术不需要使用或存在氯离子/原子和/或氯化物或氯基材料用于制造过程/最终悬浮液。 本发明还包括其药物组合物，以及双金属纳米晶体或其悬浮液或胶体在治疗或预防金属基治疗已知的疾病或病症中的应用，包括例如癌性疾病或病症 。

公开(公告)号：US20160317578A1

公开(公告)日：2016-11-03

申请号：US15204534

申请日：2016-07-07

申请人： Adam R. Dorfman ,  David A. Bryce ,  Maxwell A. Grace ,  D. Kyle Pierce ,  Mikhail Merzliakov ,  Mark G. Mortenson

发明人： Adam R. Dorfman ,  David A. Bryce ,  Maxwell A. Grace ,  D. Kyle Pierce ,  Mikhail Merzliakov ,  Mark G. Mortenson

IPC分类号： A61K33/24 ,  A61K9/16

CPC分类号： A61K33/24 ,  A61K9/10 ,  A61K9/14 ,  A61K9/1611 ,  B82Y5/00 ,  C22C1/0466 ,  C22C5/02 ,  C22C5/04 ,  C22C30/00

摘要： The present invention relates to novel gold-platinum based bi-metallic nanocrystal suspensions that have nanocrystal surfaces that are substantially free from organic or other impurities or films associated with typical chemical reductants/stabilizers and/or raw materials used in nanoparticle formation processes. Specifically, the surfaces are “clean” relative to the surfaces of metal-based nanoparticles made using chemical reduction (and other) processes that require organic (or other) reductants and/or surfactants to grow (and/or suspend) metal nanoparticles from metal ions in a solution.The invention includes novel electrochemical manufacturing apparatuses and techniques for making the bi-metallic nanocrystal suspensions. The techniques do not require the use or presence of chlorine ions/atoms and/or chlorides or chlorine-based materials for the manufacturing process/final suspension. The invention further includes pharmaceutical compositions thereof and the use of the bi-metallic nanocrystals or suspensions or colloids thereof for the treatment or prevention of diseases or conditions for which metal-based therapy is already known, including, for example, for cancerous diseases or conditions.

摘要翻译： 本发明包括用于制备双金属纳米晶体悬浮液的新型电化学制造装置和技术。 这些技术不需要使用或存在氯离子/原子和/或氯化物或氯基材料用于制造过程/最终悬浮液。 本发明还包括其药物组合物，以及双金属纳米晶体或其悬浮液或胶体在治疗或预防金属基治疗已知的疾病或病症中的应用，包括例如癌性疾病或病症 。

公开(公告)号：US20140294963A1

公开(公告)日：2014-10-02

申请号：US14008931

申请日：2012-03-30

申请人： Adam R Dorfman ,  David A. Bryce ,  Maxwell A. Grace ,  D. Kyle Pierce ,  Mikhail Merzliatov ,  Mark G. Mortenson

发明人： Adam R Dorfman ,  David A. Bryce ,  Maxwell A. Grace ,  D. Kyle Pierce ,  Mikhail Merzliatov ,  Mark G. Mortenson

IPC分类号： A61K33/24 ,  C22C1/04 ,  C22C5/02 ,  C22C30/00 ,  C22C5/04

CPC分类号： A61K33/24 ,  A61K9/10 ,  A61K9/14 ,  A61K9/1611 ,  B82Y5/00 ,  C22C1/0466 ,  C22C5/02 ,  C22C5/04 ,  C22C30/00

摘要： The present invention relates to novel gold-platinum based bi-metallic nanocrystal suspensions that have nanocrystal surfaces that are substantially free from organic or other impurities or films associated with typical chemical reductants/stabilizers and/or raw materials used in nanoparticle formation processes. Specifically, the surfaces are “clean” relative to the surfaces of metal-based nanoparticles made using chemical reduction (and other) processes that require organic (or other) reductants and/or surfactants to grow (and/or suspend) metal nanoparticles from metal ions in a solution. The invention includes novel electrochemical manufacturing apparatuses and techniques for making the bi-metallic nanocrystal suspensions. The techniques do not require the use or presence of chlorine ions/atoms and/or chlorides or chlorine-based materials for the manufacturing process/final suspension. The invention further includes pharmaceutical compositions thereof and the use of the bi-metallic nanocrystals or suspensions or colloids thereof for the treatment or prevention of diseases or conditions for which metal-based therapy is already known, including, for example, for cancerous diseases or conditions.

摘要翻译： 本发明涉及具有纳米晶体表面的新型金 - 铂基双金属纳米晶体悬浮液，其基本上不含与用于纳米颗粒形成过程中的典型化学还原剂/稳定剂和/或原料相关的有机或其它杂质或膜。 具体地说，相对于使用需要有机（或其它）还原剂和/或表面活性剂从金属生长（和/或悬浮）金属纳米粒子的化学还原（和其它）方法制备的金属基纳米颗粒的表面，表面“干净” 离子在溶液中。 本发明包括用于制备双金属纳米晶体悬浮液的新型电化学制造装置和技术。 这些技术不需要使用或存在氯离子/原子和/或氯化物或氯基材料用于制造过程/最终悬浮液。 本发明还包括其药物组合物，以及双金属纳米晶体或其悬浮液或胶体在治疗或预防已知金属基治疗的疾病或病症中的用途，包括例如癌性疾病或病症 。